Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy

ConclusionThe present study showed that C. colocynthis fruit, through its antioxidant and hypoglycemic activities, has a positive effect in the treatment of diabetic neuropathy.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research

Related Links:

Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg amputation, and neuropathic pain (painful-DPN). Unfortunately, DPN is often diagnosed late when irreversible nerve injury has occurred and its first presentation may be with a diabetic foot ulcer. Several novel diagnostic techniques are available which may supplement clinical assessment and aid the early detection of DPN. Moreover, treatments for DPN and painful-DPN are limited. Only tight glucose control in type 1 diabetes has robust evidence in re...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study demonstrated that while diabetic peripheral neuropathy deteriorates gait function, including increasing gait unsteadiness and limp, the diabetic foot ulcer and offloading combination magnifies the deterioration beyond diabetic peripheral neuropathy. These findings promote caution of the current standards of care for treating diabetic foot ulcers with offloading footwear. However, it is possible that a contralateral shoe lift may remedy deteriorated gait function and improve quality of life for unilateral offloading users.
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Source Type: research
Authors: Lu M, Yi T, Xiong Y, Wang Q, Yin N Abstract Cortex Mori Radicis extract (CMR) has various pharmacological properties, such as anti‑inflammatory, anti‑allergic and anti‑hyperglycemic effects. However, the effects and mechanisms of CMR in the neuroregeneration of diabetic peripheral neuropathy (DPN) are unclear. In the present study, the effects of CMR on neurite outgrowth of dorsal root ganglia (DRG) neurons in diabetic rats were investigated and its underlying mechanisms were explored. SD rats were subjected to a high‑fat diet with low‑dose streptozotocin to induce a Type II diabetes model with p...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Testing of protective sensation and vibration perception are two of the most commonly used non-invasive methods of screening for diabetes-related peripheral neuropathy (DPN). However, there is limited research...
Source: Journal of Foot and Ankle Research - Category: Podiatry Authors: Tags: Research Source Type: research
Conclusions The effectiveness and safety results of eribulin as the first- or second-line treatment were favorable. Thus, these suggest eribulin may be a first-line treatment candidate for patients with HER2-negative advanced breast cancer in Japan.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
This study is part of a series of two clinical trials. Taking into account the various musculoskeletal alterations of the foot and ankle in people with diabetic peripheral neuropathy (DPN) and the need for sel...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Diabetes mellitus (DM) is an important public health issues worldwide. As the incidence of diabetes increases, the incidence of complications is expected to increase accordingly [1]. DPN is one of the most common complications of DM and it is caused by persistent high glucose levels. This problem is an important cause of disability and poor quality of life in diabetic patients [2]. It is also associated with an increased incidence of foot ulcers [3]. It has been reported that amputation in people with DPN is 10 –20 times more common than the group without diabetes.
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
This study is part of a series of two clinical trials. Taking into account the various musculoskeletal alterations of the foot and ankle in people with diabetic peripheral neuropathy (DPN) and the need for self-care to avoid more serious dysfunctions and complications, a self-manageable exercise protocol that focuses on strengthening the foot muscles is presented as a potentially effective preventive method for foot and gait complications. The aim of this trial is to investigate the effect of a customized rehabilitation technology, the Diabetic Foot Guidance System (SOPeD), on DPN status, functional outcomes and gait biome...
Source: Trials - Category: Research Source Type: clinical trials
ConclusionSodium nitrate preconditioning produces a protective effect in diabetic neuropathy, which may be mediated by its antihyperglycemic effects and increased serum insulin level.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Publication date: Available online 11 January 2020Source: European Journal of RadiologyAuthor(s): Yu He, Ying Jin, Xiaoping Li, Lingyu Wu, Chunxiang JinAbstractPurposeThe aim of this study was to noninvasively explore pancreatic morphological and mechanical changes in diabetic patients with or without microangiopathy and to investigate the clinical correlations of pancreatic stiffness or size with diabetic microangiopathy.MethodsA total of 213 type 2 diabetic patients with / without microangiopathy (91/122) were prospectively enrolled. Microangiopathy included diabetic retinopathy, diabetic nephropathy and diabetic periphe...
Source: European Journal of Radiology - Category: Radiology Source Type: research
More News: Antidoxidants | Brain | Complementary Medicine | Diabetes | Endocrinology | Fruit | Gabapentin | Neurology | Neurontin | Peripheral Neuropathy | Study