Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors.

The objective response rate (ORR) was 30% (10/33), including three complete responses (CR) (9.1%) and seven partial responses (PR) (21.2%) and a disease control rate (DCR = CR + PR + SD) of 66.7% (22 of 33). The most common adverse reactions, blistering, subcutaneous fat induration, local heat-related pain, vomiting and sinus tachycardia, were observed in association with HT. IL-2, IL-4, TNF-α, and IFN-γ levels in peripheral blood were significantly increased among the clinical responders (p 
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

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Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionIn this series of patients, we have shown that metastatic LNs can be safely treated with image-guided CA. Caution should be paid, and additional measures should be taken when treating LNs near thermal-sensible structures.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionOur classification helps to choose the most proper percutaneous approach in all kinds of bile leakage, even in severe cases; these are safe techniques with a high success rate.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
AbstractA systematic review was conducted to provide an overview of the efficacy and safety of125I irradiation stent placement for patients with hepatocellular carcinoma (HCC) and main portal vein tumor thrombosis (MPVTT). Six studies with 406 patients were included in the final analysis. The median overall survival for patients treated with125I irradiation stent placement was 10.3  months. The most common radiation-related adverse event was leukopenia. The stent-related adverse events consisted of fever, abdominal pain, hemorrhage, and anorexia. No stent or seed migration was reported. Overall, the use of an125I irra...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 16 January 2020Source: Personality and Individual DifferencesAuthor(s): Arianna Vecchio, Vilfredo De PascalisAbstractPain is an unpleasant sensory and emotional experience associated with actual or potential damage to the body. The experience of acute pain reflects the continuous processing of a complex hierarchical system of motivations to act that incorporates expectations and beliefs serving to limit the impact of adverse events. Research on placebo analgesia highlights that placebo analgesia can be modulated by dispositional characteristics that interact with environmental and persona...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
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