Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy.

CONCLUSION: IV NEPA was highly effective and safe with no associated hypersensitivity and injection-site reactions in patients receiving AC. IMPLICATIONS FOR PRACTICE: As a combination of a neurokinin-1 (NK1) receptor antagonist (RA) and 5-HT3RA, NEPA offers 5-day chemotherapy-induced nausea and vomiting prevention with a single dose and an opportunity to improve adherence to antiemetic guidelines. In this randomized multinational phase IIIb study, intravenous (IV) NEPA (fosnetupitant/palonosetron) was safe and highly effective in patients receiving multiple cycles of anthracycline-cyclophosphamide (AC)-based chemotherapy. Unlike other IV NK1RAs, the IV NEPA combination solution does not require any surfactant, emulsifier, or solubility enhancer and contains no allergenic excipients. Hypersensitivity reactions and anaphylaxis have been reported with other IV NK1RAs, most commonly with fosaprepitant in the AC setting. Importantly, there were no injection-site or hypersensitivity reactions associated with IV NEPA. PMID: 31801902 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research

Related Links:

What impact do antibiotic-related changes of the gut microbiome have on efficacy of immune-checkpoint inhibitors?Annals of Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
For patients with life-altering illnesses or anyone just getting older, it helps to roll with the punches and make the best of the here and now.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cancer Elderly Books and Literature Medicine and Health Source Type: news
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Prostate Gland Prostate Cancer Vegetables Diet and Nutrition Prostate Specific Antigen Source Type: news
You are leaving AARP.org and going to the website of our trusted provider. ... The provider ’s terms, conditions and policies apply. ... Please return to AARP.org to learn more about other benefits.
Source: AARP.org News - Category: American Health Source Type: news
Publication date: Available online 19 January 2020Source: Food Research InternationalAuthor(s): Caiyu Lei, Xiangyi Tang, He Li, Hualei Chen, Shujuan YuAbstractThe grape seed extract (GSE) hybridized with medium-chain saturated fatty acids (decanoic acid) exhibited higher lipophilicity, antioxidant activity, and anti-proliferative activity than its parents. The chemical structures of individual hybridized GSE derivatives were identified as 3'-O-decanoyl catechin, 3′-O-decanoyl epicatechin, 3', 5'-2-O-decanoyl epigallocatechin, and 3', 4', 3'', 5''-4-O-decanoyl epicatechin gallate by HPLC-MS2 and 1H and 13C NMR. For gr...
Source: Food Research International - Category: Food Science Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Women whose periods stop before the age of 40 are at greater risk of diabetes, heart disease, strokes, asthma and breast cancer, the study found. The UK menopause average is 51.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
.
Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Imre Huber, Zsuzsanna Rozmer, Zoltán Gyöngyi, Ferenc Budán, Péter Horváth, Eszter Kiss, Pál PerjésiAbstractThe chemical susceptibility of the β-diketone linker between the two aromatic rings in the structure of curcumin to hydrolysis and metabolism has made it crucial to investigate structurally modified analogs of curcumin without such shortcomings. The synthesis of twenty cyclic C5-curcuminoids is described in this study in order to gain more insight into their anticancer struct...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
More News: Allergy | Allergy & Immunology | Anaphylactic Shock | Brain | Breast Cancer | Cancer | Cancer & Oncology | Chemotherapy | Dexamethasone | Neurology | Oral Cancer | Study