The effects of remifentanil used during caesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial.

[The effects of remifentanil used during caesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial]. Rev Bras Anestesiol. 2019 Nov 30;: Authors: Kutlesic MS, Kocic G, Kutlesic RM Abstract BACKGROUND AND OBJECTIVE: Remifentanil is used to attenuate maternal hemodynamic response to intubation and surgical stress during Induction-Delivery period of cesarean section. The goal was to compare the effects of two remifentanil dosing regimens on oxidative stress level, in correlation with its hemodynamic and neonatal effects. METHODS: Fifty-one patients, 17 per group, enrolled for elective cesarean section were randomly divided by computer-generated codes into three parallel groups: (A) patients received a 1μg.kg-1 remifentanil bolus immediately before induction, followed by 0.15μg.kg-1.min-1 infusion, that was stopped after skin incision; (B) patients received a 1μg.kg-1 remifentanil bolus immediately before induction; (C) (control), patients did not receive remifentanil until delivery. Maternal venous blood samples were taken at basal time, at extraction and 30minutes after the end of operation for spectrophotometrical determination of malondialdehyde and advanced oxidation protein products concentration. The same was conducted for umbilical venous sample. RESULTS: Systolic blood pressure and heart rate remained significantly lower in group A compared to B and C du...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

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Publication date: November–December 2019Source: Brazilian Journal of Anesthesiology (English Edition), Volume 69, Issue 6Author(s): Marija S. Kutlesic, Gordana Kocic, Ranko M. KutlesicAbstractBackground and objectiveRemifentanil is used to attenuate maternal hemodynamic response to intubation and surgical stress during Induction–Delivery period of cesarean section. The goal was to compare the effects of two remifentanil dosing regimens on oxidative stress level, in correlation with its hemodynamic and neonatal effects.MethodsFifty-one patients, 17 per group, enrolled for elective cesarean section were randomly ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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