Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines expression.

Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines expression. Folia Morphol (Warsz). 2019 Dec 05;: Authors: Eldomiaty MA, Elayat A, Ali S, Algaidi S, Elnaggar M Abstract Myokines; a group of cytokines mainly small proteins are released by myocytes during muscular contraction and proved to have many biological effects locally or at systemic levels. The main objective was to study the morphological alterations and myokines expression in rat gastrocnemius muscle following forced compared to voluntary muscle contraction. Thirty-six adult male Wistar rats were divided into 3 groups: control, voluntary exercise and forced swimming regimen. The experiment last for 3 weeks. The weight of rats and serum corticosterone levels were recorded. The gastrocnemius muscle samples were processed for histological and immunohistochemical study of different myokines. The mean weight of rats showed no statistical difference between groups. Corticosterone level significantly increased after forced exercise. Voluntary exercise muscle fibers appeared hypertrophied with prominent transverse banding and dominating satellite cells. Forced exercise muscle showed atrophied widely spaced muscle fibers and inflammatory cell infiltrate. Voluntary exercise significantly increased optic density of interleukin 6, macrophage inhibitory and brain derived neurotrophic factors, whereas the forced exercise group showed significan...
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research