Among Individuals Irradiated for Benign Conditions in Childhood, Developing Thyroid Cancer Does Not Affect All-cause Survival.

The objective of the current study was to determine if the development of thyroid cancer is associated with a differential survival in radiation-exposed individuals. METHODS: We conducted a matched prospective cohort mortality follow-up study based on data from a cohort of 4296 individuals who were irradiated for enlarged tonsils during their childhood (between 1939 and 1962) and were prospectively followed since 1974. The study matched an irradiated subject who developed (was exposed to) thyroid cancer (a "case") and two irradiated subjects, who had not developed (were not exposed to) thyroid cancer ("controls") by the time of case incidence. The two controls were randomly matched to cases by gender, year of birth, age at radiation treatment and radiation dose. Then, using a stratified Cox analysis, we compared survival time from the date of thyroid cancer diagnosis or time of selection to either date of death or the end of the observation period (December 31st, 2016). Vital status and causes of death were determined using the National Death Index (1979-2016), the Social Security Death Index (1974-1979), and study files. Cause of death was categorized as cardiovascular, malignancy, or other. RESULTS: A total of 1008 subjects were included in the analysis, including 353 thyroid cancer cases. At the end of the study period, 162 out of 655 (24.7%) of individuals without thyroid cancer had died compared with 100 of 353 (28.3%) of the subjects with thy...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research

Related Links:

.
Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
This study aimed to offer a reference for the rational indications of AT.Methods: We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015. These patients were allocated into two groups: Group AT and Group surgery alone (Group SA). We established a nomogram to predict OS and then divided whole cohort into low-risk and high-risk groups based on the OS predicted by the nomogram.Results: Six variables, which were significantly related with OS of entire patients after matched, were incorporated in the nomogram. These variables were age, examined lymph nodes, tum...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
In this study, we demonstrate the use of lipids as co-surfactants for the preparation of mixed micelles to improve the siRNA delivery of cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were polymerized on the surface of cholic acid to afford a star-shaped block copolymer with four arms (CA-PAGE-b-PEG)4. The allyl groups of PAGE were functionalized to bear primary or tertiary amines and folic acid was grafted onto the PEG chain end to increase cell uptake. (CA-PAGE-b-PEG)4 functionalized with either primary or tertiary amines show high siRNA complexation with close to 10...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 January 2020Source: International Journal of PharmaceuticsAuthor(s): Kharkar Prachi Balaram, Talkar Swapnil Sunil, Patravale Vandana BharatAbstractThe aim of this study is to formulate thermodynamically stable docetaxel loaded nanostructured lipid carriers (DTX-NLCs) for parenteral cancer therapy with improved long term stability and better pharmacokinetic performance. DTX-NLCswere formulated using microemulsion(ME) template technique and characterized for particle size,entrapment efficiency (EE%), drug content and in vitro release kinetics. Further evaluation of NLCs was carried out b...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
.
Source: Journal of Psychosocial Oncology - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Artificial Intelligence in MedicineAuthor(s): Asha Das, Madhu S. Nair, David Peter S.AbstractBreast cancer is the most prevalent invasive type of cancer among women. The mortality rate of the disease can be reduced considerably through timely prognosis and felicitous treatment planning, by utilizing the computer aided detection and diagnosis techniques. With the advent of whole slide image (WSI) scanners for digitizing the histopathological tissue samples, there is a drastic increase in the availability of digital histopathological images. However, these samples are...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
.
Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Publication date: Available online 24 January 2020Source: Research in MicrobiologyAuthor(s): Hong-Wei Pan, Lu-Tao Du, Wei Li, Yong-Mei Yang, Yi Zhang, Chuan-Xin WangAbstractThe host-associated gut microbiota is considered critical for the occurrence and progression of colorectal cancer (CRC); however, systematic evaluations of the changes in the biodiversity and richness of mucosa-associated gut microbiota with the development of CRC have been limited. Twenty-three paired samples from colorectal tumor sites and the surrounding non-tumor tissues were collected from stage I to IV CRC patients. The microbial compositions of t...
Source: Research in Microbiology - Category: Microbiology Source Type: research
More News: Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Child Development | Childhood Cancer | Endocrinology | Heart | Study | Thyroid | Thyroid Cancer | Tonsillitis