Building Functional Connectivity Neuromarkers of Behavioral Self-Regulation across Children with and without Autism Spectrum Disorder
We examined whole-brain brain functional correlations (FC) and behavioral regulation through connectome predictive modelling (CPM). CPM is a data-driven protocol for developing predictive models of brain–behavior relationships and assessing their potential as ‘neuromarkers’ using cross-validation. The data stems from the ABIDE II and comprises 276 children with and without ASD (8-13 years).We identified networks whose FC predicted individual differences in behavioral regulation. These network models predicted novel individuals’ inhibition and shifting from FC data in both a leave-one-out, and split halves, cross-validation. We observed commonalities and differences, with inhibition relying on more posterior networks, shifting relying on more anterior networks, and both involving regions of the DMN.Our findings substantially add to our knowledge on the neural expressions of inhibition and shifting across children with and without a neurodevelopmental condition. Given the numerous behavioral issues that can be quantified dimensionally, refinement of whole-brain neuromarker techniques may prove useful in the future.
Publication date: Available online 21 January 2020Source: Journal of Hazardous MaterialsAuthor(s): Tianyu Dong, Quanquan Guan, Weiyue Hu, Mingzhi Zhang, Yuqing Zhang, Minjian Chen, Xinru Wang, Yankai XiaAbstractGlufosinate ammonium (GLA) is a widely used organophosphate herbicide, which could be commonly detected in body fluids of both pregnant women and newborns. Existing evidences indicate that GLA has reproductive toxicity, while data concerning the effects of prenatal GLA exposure on neurodevelopment is rather limited. Here we employed a mouse model exposed to GLA prenatally. Reduced locomotor activity, impaired memory...
A specialist care facility in England is using virtual reality (VR) headsets and data mining to help children with autism to acclimatize to scenarios they are likely to encounter outside of school.
Conditions: Traumatic Dental Injury; Autism Spectrum Disorder; Dental Trauma Intervention: Sponsor: Cairo University Not yet recruiting
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Bichao Lu, Fanyong Zeng, Wen Xing, Lin Liang, Jianbo Huo, Chianru Tan, Lingxiang Zhu, Zhizhong LiuAbstractBackgroundMitochondrial DNA copy number is a potential biomarker for mitochondrial dysfunction and is involved in a variety of disease states including autism, neurodegenerative diseases and traumatic brain injury, but few studies on mitochondrial DNA copy number in cerebral palsy have been reported. Therefore, this study aims to investigate the role of mitochondrial DNA copy number in children with cerebral palsy.MethodsA total of...
According to a study published inMolecular Autism and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, men with autism form stronger emotional bonds with others after being given oxytocin.MedicalXpress
(University of Colorado Anschutz Medical Campus) After showing that a 10-week therapeutic horseback riding intervention reduced irritability and hyperactivity while improving the social communication skills of youth diagnosed with autism spectrum disorder (ASD), University of Colorado Anschutz Medical Campus researcher and Children's Hospital Colorado psychologist, Dr. Robin Gabriels, has received a $2.5 million grant to investigate why the therapy works.
ConclusionThese results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization.
AbstractObjectiveTo evaluate the long-term pediatric neuropsychiatric morbidity of children born to obese patients.Study designA population-based cohort analysis was performed comparing all deliveries of obese (maternal pre-pregnancy body mass index of 30 kg/m2 or more) and non-obese patients between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18 years involving neuropsychiatric morbidities were evaluated according to a pre-defined set of ICD-9 codes, including autistic, eating, sleeping and movement disorders, cerebral palsy, developmental disorders, an...
ConclusionThe design and implementation of more scalable methods to disseminate research remotely can substantially improve access to clinical trials in rare neurodevelopmental disorders. The lessons learned from this trial can serve as a model for future studies not only in rare conditions, but in other populations that lack adequate access, such as families with limited financial or clinical resources. Continued efforts will further refine delivery methods to enhance efficiency and ease of these delivery systems for families.