Molecules, Vol. 24, Pages 4474: Amelioration of Hyperglycemia-Induced Nephropathy by 3,3 ′-Diindolylmethane in Diabetic Mice

In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. In mice, STZ induced hyperglycemia, hunger, thirst, and abnormally increased kidney weight and serum creatinine, which is a renal functional parameter. DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-α and TGF-β1 signaling.

Source: Molecules - December 5, 2019 Category: Chemistry Authors: Kyeong-Mi Choi Hwan-Soo Yoo Tags: Article Source Type: research