Characterization of NCS1-InsP3R1 interaction and its functional significance [Cell Biology]

In conclusion, we show that NCS1–InsP3R1 interaction enhances intracellular Ca2+ signaling in cells and can be modulated by altering or occluding the hydrophobic pocket of NCS1. This improved understanding of the NCS1–InsP3R1 interaction may facilitate the development of management strategies for diseases resulting from aberrant NCS1 expression.

Source: Journal of Biological Chemistry - December 5, 2019 Category: Chemistry Authors: Lien D. Nguyen, Edward T. Petri, Larry K. Huynh, Barbara E. Ehrlich Tags: Signal Transduction Source Type: research