The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.

This study may contribute to understand metabolic disorders such as type 2 diabetes mellitus and morbid obesity and implements alternative therapeutic approaches to alter AMPK activity.Abbreviations: ACTB: actin, beta; ADP: adenosine diphosphate; AMP: adenosine monophosphate; AMPK: AMP-activated protein kinase; ARMC8: armadillo repeat containing 8; ATP: adenosine triphosphate; BafA1: bafilomycin A1; BCAA: branched chain amino acid; BICC1: BicC family RNA binding protein 1; BSA: bovine serum albumin; CAMKK2 kinase: calcium/calmodulin dependent protein kinase kinase 2, beta; CHX: cycloheximide; DMEM: Dulbecco's modified Eagle's medium; E1: ubiquitin-activating enzyme; E2: ubiquitin-conjugating enzyme; E3: ubiquitin ligase; ECAR: extracellular acidification rate; FACS: fluorescent associated cell sorter; FBP1: fructose-bisphosphatase 1; FCCP: carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone; G6P: glucose-6-phosphate; GDP: guanosine diphosphate; GFP: green fluorescent protein; GID: glucose induced degradation deficient; GMP: guanosine monophosphate; GTP: guanosine triphosphate; HBP1: high mobility group box transcription factor 1; HPRT: hypoxanthine guanine phosphoribosyl transferase; KO: knock out; LE: long exposure; MAEA: macrophage erythroblast attacher; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MKLN1: muskelin 1; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin; NES: normalized enrichment score; OCR: oxygen consumption rate; PBS: phosp...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research

Related Links:

Conclusions: The intake of calcium, folic acid and magnesium was negatively associated with blood glucose levels in individuals in different quantiles of FPG. Appropriate prevention and treatment strategies should be developed for people with different blood glucose levels. PMID: 31983911 [PubMed]
Source: Food and Nutrition Research - Category: Nutrition Tags: Food Nutr Res Source Type: research
A new study found that women who were obese or older walked with greater relative effort compared with healthy-weight and younger women. What may account for these differences?Medicine and Science in Sports and Exercise
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news
What are the signs and symptoms of youth-onset type 2 diabetes, and how is this disease best managed?Pediatric Nursing
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nursing Journal Article Source Type: news
TYPE 2 diabetes is a chronic condition which affects the body in many ways. The condition is a global epidemic with more and more people being diagnosed with type 2 diabetes. Noticing a peculiar feeling in your eyes could mean you're at risk of developing the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Our results indicate the potential role of immediate (5 min) or early (15 min) acquisition in replacement of standardized 240 minutes acquisition in PD patients, but this result is not confirmed in HF patients, in which the acquisition at 240 min is confirmed as the most affordable timing for image interpretation, emphasizing the different pathophysiology that underlies these two pathologies. PMID: 31985388 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
CONCLUSIONS AND CLINICAL RELEVANCE: In this sample of dogs with well-controlled diabetes mellitus, addition of lispro insulin to an existing treatment regimen of NPH insulin and dietary management significantly decreased postprandial BGCs. Further study of BBIT for dogs with diabetes mellitus is warranted. PMID: 31985281 [PubMed - in process]
Source: American Journal of Veterinary Research - Category: Veterinary Research Authors: Tags: Am J Vet Res Source Type: research
Conclusions: This study suggests that differential expression of CRAC channel correlated with the expression of inflammatory cytokines, thus CRAC channel might be responsible for the increased production of inflammatory cytokines in the alloxan induced T1D mice. PMID: 31983259 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
(University of South Florida (USF Health)) A study led by researchers at the University of South Florida Morsani College of Medicine discovered that three major proinflammatory mediators -- interlukin-1 beta, tumor necrosis factor alpha, and thrombin -- individually and especially when combined, directly drive capillary loss known to occur in diseases such as hypertension, diabetes, cardiovascular diseases, neurodegenerative diseases and malignant cancer. Using an innnovative 3-D cell model, the investigators also identified combinations of existing drugs that can block the regression of these tiny blood vessels.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Authors: Bhatwadekar AD, Kansara V, Ciulla T Abstract Introduction: Plasma kallikrein is a mediator of vascular leakage and inflammation. Activation of plasma kallikrein can induce features of diabetic macular edema (DME) in preclinical models. Human vitreous shows elevated plasma kallikrein levels in patients with DME. Because of the incomplete response of some patients to anti-VEGF agents, and the treatment burden associated with frequent dosing, there is still considerable need for VEGF-independent targeted pathways.Areas Covered: This review covers the role of plasma kallikrein in the pathogenesis of DME and th...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Authors: Han Z, Wang Z, Song C, Sheng J, Niu X, Qi P PMID: 31985185 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
More News: Calcium | Cytology | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Eating Disorders & Weight Management | Endocrinology | Genetics | Obesity | Study | Tuberous Sclerosis