Automated phenotyping of patients with non-alcoholic fatty liver disease reveals clinically relevant disease subtypes.

In this study, we used data mining techniques to search for subtypes in an unbiased fashion. Using electronic signatures of the disease, we identified a cohort of 13,290 patients with NAFLD from a hospital database. We gathered clinical data from multiple sources and applied unsupervised clustering to identify five subtypes among this cohort. Descriptive statistics and survival analysis showed that the subtypes were clinically distinct and were associated with different rates of death, cirrhosis, hepatocellular carcinoma, chronic kidney disease, cardiovascular disease, and myocardial infarction. Novel disease subtypes identified in this manner could be used to risk-stratify patients and guide management. PMID: 31797589 [PubMed - in process]
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research

Related Links:

Publication date: Available online 16 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Minjing Shao, Chuanjun Zhuo, Xiangyang Gao, Ce Chen, Yong Xu, Hongjun Tian, Gongying Li, Deguo Jiang, Wenqiang WangAbstractImportanceIt has been suggested that patients with schizophrenia have higher than expected mortality following acute coronary events. However, the in-hospital revascularization rate in patients with schizophrenia and acute myocardial infarction (AMI) compared to mentally healthy patients remains unknown.ObjectiveTo evaluate the revascularization rate in schizophrenic patien...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Authors: Skalický T, Skalický A Abstract The presented case report describes primarily an unrecognized liver injury after the resuscitation with cardiac massage due to myocardial infarction. After myocardial revascularization, the hemodynamic instability and anaemia in the patient persisted. The performed CT scan confirmed a liver injury, namely the rupture of liver parenchyma with hemoperitoneum, which had to be treated surgically. It represents a complication of cardiac massage that occurs, though less frequently. Key words: resuscitation, liver trauma. PMID: 31941573 [PubMed - in process]
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
We describe three new settings in which ASE improves the detection of a variety of antibodies applied on long-time stored non-human primate brain sections, cell culture monolayers and on squamous carcinomas retrieved from cervical cancer patients. The significant improvement of ASE over optimized immunohistochemical protocols used in clinical practice (i.e. cancer detection) combined with its simplicity and low cost makes it an attractive method for biomedical applications.
Source: Neuroscience - Category: Neuroscience Source Type: research
Authors: Yildirim M, Kaplan M, Duzenli T, Tanoglu A, Kucukodaci Z, Onal Tastan Y, Cakir Guney B, Serindag Z Abstract Background: To investigate the protective efficacy of pentoxifylline through biochemical parameters and histopathological scores in a caerulein- and alcohol-induced experimental model of chronic pancreatitis in rats.Methods: A model of chronic pancreatitis with caerulein and alcohol was created in female rats of the genus Sprague Dawley. Pentoxifylline was administered in doses of 25 mg/kg (low dose) and 50 mg/kg (high dose) as a protective agent. Each group contained 8 animals. The gro...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 16 January 2020Source: Journal of Food EngineeringAuthor(s): Luís Marangoni Júnior, Léa Mariza de Oliveira, Paula Fernanda Janetti Bócoli, Marcelo Cristianini, Marisa Padula, Carlos Alberto Rodrigues AnjosAbstractThe effect of high-pressure processing on the morphological surface, thermal and mechanical properties of three PA and EVOH based multilayer flexible packaging materials were evaluated. LDPE/PA/LDPE, LDPE/EVOH/LDPE and PET/LDPE/PA/EVOH/PA/LDPE packaging samples were processed under three different conditions (600 MPa/25 °C/10 min, 600 MPa/90 °C...
Source: Journal of Food Engineering - Category: Food Science Source Type: research
Most people know about the damaging effects that binge drinking can bring to someone’s life. Loss of enjoyment of life, losing family relationships, financial and career struggles, homelessness, and legal consequences are just the tip of the iceberg. However, it can be more difficult to realize the long-term effect of binge drinking on the body, because you cannot always see it. Frequent binge drinking poses many dangerous health risks, and many of them can lead to death. Facts on Long-Term Effect of Binge Drinking on the Body For men, binge drinking is defined as consuming five or more drinks within about two hour...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol treatment alcohol treatment center binge binge drinking Source Type: blogs
With all the advances in modern medicine, it can be easy to wonder if there is a medication to stop drinking. Unfortunately, getting sober from alcohol isn’t as easy as simply taking medication. In addition to medication, therapy is required for the best long-term results, as well as support from loved ones and ongoing aftercare. However, there are some medications to help along in the process to stop withdrawal symptoms, block cravings, and create an aversion to alcohol. It is important to not rely only on medication to stop drinking. A commitment to behavioral therapy, holistic therapy, family involvement, self-ca...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol dependence alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Source Type: blogs
Alcohol is a toxic substance that can wreak havoc on the body, brain, central nervous system, internal organs, behavior patterns, emotions, and more. Long-term alcohol abuse can lead to serious damage to the body which, in some cases, can be irreversible and lead to certain chronic conditions. Detoxing from alcohol can present its own set of dangerous withdrawal symptoms and, as such, it is important to know what you need when you are ready to safely detoxify alcohol from your system. Preparation to Detoxify Alcohol When you’re ready to detoxify alcohol from your system, it is important that you and your loved ones ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol dependence alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use Source Type: blogs
This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-visible barriers and has potential applications in thermal insulating materials for food preservation.Graphical abstract
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 17 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Kara A. DeSantis, Samantha L. Robilotto, Mark Matson, Noor M. Kotb, Cathryn M. Lapierre, Zenab Minhas, Alana A. Leder, Khushbakht Abdul, Emily M. Facteau, JoEllen WelshAbstractThe vitamin D receptor (VDR) and its ligand 1,25(OH)2D3 (1,25D) impact differentiation and exert anti-tumor effects in many tissues, but its role in salivary gland has yet to be defined. Using immunohistochemistry (IHC), we have detected strong VDR expression in murine and human salivary gland ducts. Compared to normal gland, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
More News: Alcoholism | Bioinformatics | Cancer & Oncology | Carcinoma | Cardiology | Cardiovascular | Chronic Kidney Disease | Cirrhosis | Databases & Libraries | Fatty Liver Disease (FLD) | Heart | Heart Attack | Hepatocellular Carcinoma | Hospitals | Liver | Liver Cancer | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Statistics | Study | Urology & Nephrology