Castleman Disease: An Uncommon Mass in the Retroperitoneum

A 34 year-old female with Stage V chronic kidney disease secondary to a history of sickle cell anemia and focal segmental glomerulosclerosis and on peritoneal dialysis presented to our hospital for imaging as part of routine evaluation for renal transplant. Upon receiving an MRI of the abdomen to evaluate liver architecture and kidney anatomy, a 6.6 cm left perinephric mass was incidentally found inferomedial to the left kidney and extending caudally (Figure 1). The renal parenchyma and ureter were uninvolved.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Grand Rounds Source Type: research

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(The Society of Thoracic Surgeons) Legendary heart-lung transplant surgeon, researcher, and professor Sir Magdi Habib Yacoub, MD, today was honored with the 2020 Earl Bakken Scientific Achievement Award from The Society of Thoracic Surgeons.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
You could say that one reason we can make simple decisions each day with relative ease is that we only have a handful of options to choose from, and that makes it easier to make a reasonably good choice. For instance, if you only have so much food in your home, or so many stores and restaurants within reach, then you may find it easier to decide what to eat each day. You don’t have to consider infinite options. You narrow your focus to what’s most accessible. But what about making bigger life choices, like what career path to explore next? This is a situation where you may feel like you’re drowning ...
Source: Steve Pavlina's Personal Development Blog - Category: Psychiatry & Psychology Authors: Tags: Creating Reality Lifestyle Source Type: blogs
Publication date: Available online 26 January 2020Source: Advances in Biological RegulationAuthor(s): Andrew T. Hale, Rachel E. Brown, Zigmund Luka, Benjamin H. Hudson, Pranathi Matta, Christopher S. Williams, John D. YorkAbstract:Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3’-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic t...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
In conclusion, advance directives are important to avoid unwanted medical interventions, including simple interventions to address life-threatening conditions. But advance directives cannot preclude someone from entering dementia—to do that, one needs to consider VSED while having capacity. At the point of dementia, standard of care comfort care, with an appropriate strategy of feeding, should be provided.  
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: End of Life Care Health Care advance directives Author: Shelton dementia syndicated Source Type: blogs
A new study indicates that the antithrombotic efficacy of NOACs are reduced in anemic patients. Should patients with AF and moderate to severe anemia receive oral anticoagulants?European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Contributors : Daniel Baumann ; Rienk OffringaSeries Type : Expression profiling by arrayOrganism : Mus musculusCancer types with lower mutational load and a non-permissive tumor microenvironment are intrinsically resistant to immune checkpoint blockade. While the combination of cytostatic drugs and immunostimulatory antibodies constitutes an attractive concept for overcoming this refractoriness, suppression of immune cell function by cytostatic drugs may limit therapeutic efficacy. Here we show that targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) does not impair dendritic cell-mediated T-cell p...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Contributors : Alexander Azzo ; Xiaofei Yu ; Mikhail Dozmorov ; Gordon D GinderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs high fetal hemoglobin (HbF) levels ameliorate the underlying pathophysiologic defects in sickle cell anemia and β-thalassemia, understanding the mechanisms that enforce silencing of HbF postnatally offers the promise of effective molecular therapy. Depletion of Methyl cytosine Binding Domain protein 2 (MBD2) causes a 10-20 fold increase in γ-globin gene expression in adult β-YAC transgenic mice. To determ ine the effect of MBD2 depletion in ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Authors: Pastor-Galán I, Hernández-Boluda JC, Correa JG, Alvarez-Larrán A, Ferrer-Marín F, Raya JM, Ayala R, Velez P, Pérez-Encinas M, Estrada N, García-Gutiérrez V, Fox ML, Payer A, Kerguelen A, Cuevas B, Durán MA, Ramírez MJ, Gómez-Casares MT, Mata-Vázquez MI, Mora E, Martínez-Valverde C, Arbelo E, Angona A, Magro E, Antelo ML, Somolinos N, Cervantes F, en representación del Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN) Abstract BACKGROUND AND OBJECTIVE MYELOFIBROSIS: is an infrequen...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
AbstractBackgroundThe purpose of this study is to investigate the performance of dual-layer detector spectral CT for iron deposition compared to magnetic resonance imaging (MRI) T2* imaging.MethodsThirty-one patients with a clinical history of myelodysplastic syndromes and aplastic anemia underwent liver and cardiac T2*-weighted unenhanced MRI on a three-tesla MRI scanner, and underwent unenhanced CT scan laterally on a 128-row spectral detector CT. R2* values of the liver, septal muscle, and paraspinal muscle were calculated. Attenuation differences ( ΔH) in the liver and myocardium were calculated between the lower...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
More News: Anatomy | Anemia | Chronic Kidney Disease | Dialysis | Hospitals | Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | Peritoneal Dialysis | Sickle Cell Anemia | Transplant Surgery | Transplants | Ureter and Renal Pelvis Cancer | Urology & Nephrology