GSE141522 Large-scale screening of circulating microRNAs in individuals with HIV-1 mono-infections reveals specific liver damage signatures

Contributors : Sandra Franco ; Daniela Buccione ; Raquel Pluvinet ; Beatriz Mothe ; Lidia Ruiz ; Maria Nevot ; Ana Jordan-Paiz ; Laia Ramos ; Susanna Auss ó ; Rosa M Morillas ; Lauro Sumoy ; Miguel A Martinez ; Cristina TuralSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman immunodeficiency virus type 1 (HIV-1)-induced inflammation and/or long-term antiretroviral drug toxicity may contribute to the evolution of liver disease. We investigated circulating plasma microRNAs (miRNAs) as potential biomarkers of liver injury in patients mono-infected with HIV-1. We performed large-scale deep sequencing analyses of small RNA level on plasma samples from patients with HIV-1 mono-infection that had elevated or normal levels of alanine aminotransferase (ALT) or focal nodular hyperplasia (FNH). Hepatitis C virus (HCV) mono-infected patients were also studied. Compared to healthy donors, patients with HIV-1 or HCV mono-infections showed significantly altered (fold change>2, adjusted p
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research