Renal Nerve Ablation for Hypertensive patients with Chronic Kidney Disease.

Renal Nerve Ablation for Hypertensive patients with Chronic Kidney Disease.
Curr Vasc Pharmacol. 2013 Jul 31;
Authors: Papademetriou V, Doumas M, Anyfanti P, Faselis C, Kokkinos P, Tsioufis K
Abstract
Among current epidemics, chronic kidney disease (CKD) is accompanied with high morbidity and mortality rates inherently associated with the thriving comorbidities of hypertension and cardiovascular disease. In this mutually reinforcing triad, adequate control of high blood pressure emerges as extremely important for decreasing patients' complication rates and prolonging life expectancy. However, hypertension control in this particular group of patients is often proven an arduous task, presenting high rates of resistance. Sympathetic nervous system (SNS) overactivity is implicated not only in the pathophysiological basis of difficult-to-treat hypertension, but also in the development and progression of renal disease, thus rendering SNS a prime therapeutic target in CKD. As renal nerve ablation (RNA) is finding its place among other invasive procedures in the cardiovascular arena, the potential therapeutic impact of this innovative treatment modality is gradually expanding from resistant hypertension to other high blood pressure-related clinical conditions like CKD. Encouraging results of clinical trials testing efficacy and safety of renal nerve ablation in resistant hypertensives provide the opportunity to apply the procedure in other subgroups o...

Source: Current Vascular Pharmacology - July 31, 2013 Category: Drugs & Pharmacology Authors: Papademetriou V, Doumas M, Anyfanti P, Faselis C, Kokkinos P, Tsioufis K Tags: Curr Vasc Pharmacol Source Type: research