Similarities and Differences Between Renal Sympathetic Denervation and Carotid Baroreceptor Stimulation.

Similarities and Differences Between Renal Sympathetic Denervation and Carotid Baroreceptor Stimulation.
Curr Vasc Pharmacol. 2013 Jul 31;
Authors: Grassi G, Seravalle G, Brambilla G, Cesana F, Cristina Giannattasio C, Mancia G
Abstract
The two novel approaches recently introduced for the treatment of resistant hypertension, i.e. carotid baroreceptor stimulation and renal denervation, share a number of similarities but are also characterized by important differences. The similarities include the evidence that both interventions have as common pathophysiological background the state of sympathetic overdrive characterizing essential hypertension. In addition both procedures 1) are invasive, 2) exert in the short-term period clearcut blood pressure lowering effects and 3) still face a number of open questions, particularly related to the long-term blood pressure lowering effects, impact on end-organ damage and on cardiovascular events. The differences include the fact the two procedures act on distinct targets that trigger sympathetic activation and consequently blood pressure increase. In addition, only in the case of carotid baroreceptor stimulation the blood pressure effects can be easily assessed immediately following the implantation. Finally, the economic costs, metabolic effects and impact on vagal modulation of heart rate are different between the two interventions. This paper will provide a comparison of the background, effects and outco...

Source: Current Vascular Pharmacology - July 31, 2013 Category: Drugs & Pharmacology Authors: Grassi G, Seravalle G, Brambilla G, Cesana F, Cristina Giannattasio C, Mancia G Tags: Curr Vasc Pharmacol Source Type: research