Study of ANX007 in Participants With Primary Open-angle Glaucoma
Condition: Open Angle Glaucoma Interventions: Biological: 2.5mg ANX007; Biological: 5.0mg ANX007; Other: Sham Procedure Sponsor: Annexon, Inc. Completed
Sensors, guidewire assemblies, glaucoma implants, bioresorbable polymer anchors, screws, tacks, and slow-release point-of-use drug-delivery devices are just some examples of micro-sized implantable products that have special design and manufacturing needs. OEMsÂ designing these innovative devices might assume that they can just go to their usual component suppliers for smaller versions of what they would use for a larger device. This can be a determinant to success, Donna Bibber, vice president of business development at Isometric Micro Molding Inc., toldÂ MD+DI,Â because tiny parts require...
Conclusion: Joint optic disc and cup segmentation, which utilizes the connection between optic disc and cup, could improve the performance of optic disc and cup segmentation. Significance: The proposed method improves the accuracy of glaucoma detection. It is promising to be used for glaucoma screening.
(Flinders University) Researchers have identified 107 genes that increase a person's risk of developing the eye disease glaucoma, and now developed a genetic test to detect those at risk of going blind from it. The research, led by QIMR Berghofer Medical Research Institute and Flinders University in Australia, has been published today in the international Nature Genetics journal.
Condition: Glaucoma, Open-Angle Intervention: Drug: Netarsudil Ophthalmic Sponsor: University of the Incarnate Word Recruiting
Conclusion: The study concludes that higher age, higher vertical cup disc ratio (VCDR), and lower central corneal thickness (CCT) are important independent predictors of OAG and emphasizes that increased intraocular pressure (IOP) is not POAG. Gonioscopy, disc evaluation, and screening perimetry need to be incorporated in the detection protocol for glaucoma if we intend to lighten the burden of blindness due to glaucoma.
This study aims to evaluate the efficacy and safety of XEN45 gel stent (Allergan plc, Dublin, Ireland) in East Asian patients with glaucoma.MethodsA retrospective study of consecutive XEN45 gel stent implantation surgeries with or without concurrent cataract surgery from May 2017 to August 2018 was performed in a single institution. The clinical charts of all cases were reviewed to examine the safety and efficacy of the implant. Primary outcome measures were intraocular pressure (IOP), number of topical glaucoma medications required, additional procedures done and adverse outcomes. All patients included were required to fu...
CONCLUSION: Metabolic health status and obesity were significantly associated with increased risk of POAG incidence. MUNO subjects but not MHO subjects showed a higher risk of POAG development than did MHNO subjects, suggesting that metabolic status is more important than obesity in POAG. PMID: 31950773 [PubMed - as supplied by publisher]
Authors: Wang M, Li J, Zheng Y Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) acts as a regulator of many biological processes and plays an essential role in preventing oxidation, inflammation, and fibrosis. In the past 20 years, there has been increasing research on the role of Nrf2 and oxidative stress in human glaucoma, including the roles of inflammation, trabecular meshwork cells, retinal ganglion cells, Tenon's capsule, antioxidants, fibrosis, and noncoding RNAs. Studies have shown that the upregulation of Nrf2 can reduce damage from oxidative stress in the trabecular meshwork cells and the retin...
Conditions: Glaucoma; Eye Diseases; Cornea Disease Interventions: Procedure: Transscleral cyclphophotocoagulation using the Micropulse system ( IRIDEX IQ810 Laser systems, Mountain View, CA).; Procedure: G-Probe transscleral cyclphophotocoagulation (Iris Medical Instruments, Montain View, CA) Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Fonds de recherche en ophtalmologie de l'Université de Montréal Not yet recruiting