Neuroprotective effects of curcumin through autophagy modulation

AbstractAutophagy is a highly conservedcellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to be associated with pathological conditions, including neurodegenerative diseases. Curcumin is a polyphenol found in the rhizome ofCurcuma longa, which has been shown to exert health benefits, such as antimicrobial, antioxidant, anti ‐inflammatory, and anticancer effects. There is increasing evidence in the literature revealing that autophagy modulation may provide neuroprotective effects. In light of this, our current review aims to address recent advances in the neuroprotective role of curcumin‐induced autophagy modulation , specifically with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, traumatic brain injury, and Parkinson's disease.

Source: IUBMB Life - December 4, 2019 Category: Research Authors: Fatemeh Forouzanfar, Morgayn I. Read, George E. Barreto, Amirhossein Sahebkar Tags: CRITICAL REVIEW Source Type: research