Progress in malaria prevention questioned by experts

Call for inquiry into pace of improvement amid statistical inconsistencies
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news

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In this study, we investigated the role of GBP2 in virulence and sexual development of P. berghei using gbp2-deleted P. berghei (Δgbp2 parasites). Then, to identify factors affected by gbp2 deletion, we performed a comparative proteomic analysis of the Δgbp2 parasites. We found that GBP2 was not associated with the development of experimental cerebral malaria during infection with P. berghei, but asexual development of the parasite was delayed with deletion of gbp2. However, the development of P. berghei gametocytes was significantly reduced with deletion of gbp2. Comparative proteomic analysis revealed that th...
Source: Parasitology International - Category: Parasitology Source Type: research
CHERYL, best known for being a member of Girls Aloud and for judging talent show competitions such as The Greatest Dancer, was left fighting for her life back in 2010 after contracting malaria.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
AbstractPlasmodium falciparum is the cause of malaria and has become resistant to the drugs used to treat the disease. Therefore, the development for novel compounds with antimalarial activity has become urgent. Plant species, such as naphthoquinone-richEleutherine plicata, may provide novel substances that exhibit antimalarial activity and serve as an alternative for the treatment of this disease. From this plant species, ethanol extracts were obtained, fractionated, and the isolated substances eleutherin, and isoleutherin were characterized by nuclear magnetic resonance. There in vitro activity againstPlasmodium falcipar...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Date: Friday, 01 24, 2020; Speaker: Peter D. Crompton, M.D., M.P.H. , Chief, Malaria Infection Biology and Immunity Unit , Laboratory of Immunogenetics, NIAID ; Building 1; Wilson Hall ; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
In this study, we analyzed 677,423 human body temperature measurements from three different cohort populations spanning 157 years of measurement and 197 birth years. We found that men born in the early 19th century had temperatures 0.59°C higher than men today, with a monotonic decrease of -0.03°C per birth decade. Temperature has also decreased in women by -0.32°C since the 1890s with a similar rate of decline (-0.029°C per birth decade). Although one might posit that the differences among cohorts reflect systematic measurement bias due to the varied thermometers and methods used to obtain temperatures, we...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serologica...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Methodology Source Type: research
Malaria prevalence has significantly reduced since 2000, largely due to the scale-up of vector control interventions, mainly indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs). Gi...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Opinion Source Type: research
Anopheles maculipennis complex, the historic vector of malaria, causes serious medical problems worldwide and exhibits different behaviours. Studying the odorant-binding proteins (OBPs), which influence the chemo...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
The larval environment of holometabolous insects determines many adult life history traits including, but not limited to, rate and success of development and adult lifespan and fecundity. The ancient stress signaling hormone abscisic acid (ABA), released by plants inundated with water and by leaf and root fragments in water, is likely ubiquitous in the mosquito larval environment and is well known for its wide ranging effects on invertebrate biology. Accordingly, ABA is a relevant stimulus and signal for mosquito development. In our studies, the addition of ABA at biologically relevant levels to larval rearing containers a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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