Hematology and Oncology: Images in Clinical Medicine

Editor: V. Dimov, M.D., Assistant Professor at University of ChicagoDisseminated Cryptococcosis in a CLL patient. NEJM, 05/2014.Leukemia cutis. Lancet, 10/2012.Biliary ileus. Lancet, 07/2012.Corneal snowflakes due to IgG-kappa multiple myeloma. Lancet, 08/2012.Splenic Spirals due to hepatoblastoma. NEJM, 06/2012.Hypertrophic Pulmonary Osteoarthropathy and Tripe Palms due to lung cancer. NEJM, 01/2012.Metastasis of Renal-Cell Carcinoma. NEJM, 10/2011.Amelanotic choroidal melanoma. Lancet, 03/2011.Retroperitoneal liposarcoma with lamellar bone inside.A painful cranial bulge. Lancet, 05/2011.Splenic Calcification in sickle cell disease. NEJM, 09/2011.Chemotherapy-Induced Hyperpigmentation of the Tongue. NEJM, 09/2011.Radiographic Zebra Lines from Cyclical Pamidronate Therapy. NEJM, 07/2011.Melanonychia Striata. NEJM, 03/2011.Lingual Hematoma after Thrombolytic Therapy. NEJM, 02/2011.Palmar –Plantar Rash with Cytarabine Therapy. NEJM, 01/2011.Extramedullary haemopoiesis causes spinal cord compression. Lancet, 01/2011.Calcified Object in the Mid-Maxilla. NEJM, 11/2010.Acoustic Findings in a Patient with Radiation Pneumonitis. NEJM, 11/2010.A White Hand and a Red Hand - Erythromelalgia. NEJM, 10/2010.Radiation Proctitis. NEJM, 09/2010.Gestational Pituitary-Tumor Apoplexy. NEJM, 08/2010.Retinal Hemangioblastoma in von Hippel –Lindau Disease. NEJM, 08/2010.Liposarcoma of the Anterior Mediastinum and Neck. NEJM, 08/2010.Serpentine Supravenous Hyperpigmentation. NEJM, ...
Source: Clinical Cases and Images - Category: General Medicine Tags: Hematology Images Oncology Source Type: news

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Contributors : David Ulmert ; Robert J KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted alpha therapy.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Lewis Liu ; Sonya A MacParland ; Jeff C Liu ; Gary D Bader ; Ian D McGilvraySeries Type : Expression profiling by high throughput sequencingOrganism : Marmota monaxWe characterized the identity of hepatic macrophages from the uninvolved liver of a WHV-positive (area with no visible tumor) tumor bearing woodchuck that take up NPs using RNA-sequencing (RNA-seq). Data from WHV-infected animal from experiment 3.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Marmota monax Source Type: research
In this study, we identified reliable miRNA clusters that can be used to subclassify HNSCC tumors as well as other squamous tumors of other anatomic locations. An institutional discovery cohort was generated using miRNA expression data from microarrays, and this was validated using publicly available next-generation microRNA sequencing data from TCGA. Further analysis of these subtypes revealed distinct biological and clinical features of HNSCC tumors based on the miRNA expression profiles, which provides new insights into the pathogenesis and treatment of HNSCC.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Contributors : Samir Devalaraja ; Tsun K To ; Ian W Folkert ; Ramakrishnan Natesan ; Zahidul Alam ; Minghong Li ; Yuma Tada ; Konstantin Budagyan ; Mai Dang ; Li Zhai ; Graham P Lobel ; Gabrielle E Ciotti ; T K Eisinger-Mathason ; Irfan A Asangani ; Kristy Weber ; M C Simon ; Malay HaldarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : OtherOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Heloisa H Milioli ; Neil PortmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we characterise the response of models of ER-positive breast cancer to treatment with the small molecule MDM2 inhibitor NVP-CGM097, a dihydroisoquinolinone derivative currently evaluated in a phase I clinical trial. We show that NVP-CGM097 reduces tumour cell viability of in vitro and in vivo models of endocrine sensitive, endocrine resistant and palbociclib (CDK4/6 inhibitor) resistant p53 wildtype (p53wt) ER-positive breast cancer. NVP-CGM097 synergises with both fulvestrant and palbo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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