Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome
AbstractBackgroundThe symptoms of irritable bowel syndrome (IBS) lead to considerable impairment of health-related quality of life and high health care costs. Available therapies are not efficient in treating the symptoms of IBS. Studies have shown the beneficial effects ofSaccharomyces cerevisiae CNCM I-3856. Therefore, this study was done to evaluate the efficacy and safety ofS. cerevisiae CNCM I-3856 in the treatment of IBS.MethodsThis was a prospective, randomized, placebo-controlled study. One hundred newly diagnosed subjects with IBS were subgrouped into IBS-D, IBS-C, and IBS-M and then randomized to theS. cerevisiae CNCM I-3856 and placebo groups.Saccharomyces cerevisiae/placebo was administered in addition to standard treatment for a period of 8 weeks. Subjects were assessed for improvement of abdominal pain and change in stool consistency using a 7-point Likert scale and Bristol stool scale respectively.ResultsThe mean reduction of abdominal pain score in theS. cerevisiae CNCM I-3856 group was statistically significant when compared with the placebo group (p
Crohn ’s disease (CD) is a chronic, immune-mediated condition associated with abdominal pain, psychological comorbidities, and reduced quality of life (QoL), even in remission. Clinical hypnosis, involving focused relaxation and therapeutic suggestion, is helpful for irritable bowel syndrome, pain, and anxiety, and may have anti-inflammatory effects. Study Aims: To implement hypnosis as an adjunctive therapy for adolescents with CD. To assess the impact on QoL, abdominal pain, psychosocial measures, and disease activity compared to standard care.
Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are characterized by recurrent abdominal pain, altered bowel habits, and psychological distress. Gastrointestinal (GI) symptom-specific anxiety (GSA) is the cognitive, affective, and behavioral response stemming from anxiety and fear of GI symptoms. The Visceral Sensitivity Index (VSI) measures GSA and is validated in IBS but may also be a useful measure in IBD. We previously showed that VSI scores (increased GSA) are significantly higher in adult IBD patients with mild disease activity vs.
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues. Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Conclusions: Stool microbial diversity and composition are linked to daily extraintestinal symptoms, stool consistency, and QOL in women with IBS.
Conclusions: Phloroglucinol could be a safe and beneficial option for the management of overall IBS symptoms in patients with IBS-D. Further large scaled studies are warranted. PMID: 31917916 [PubMed]
Authors: Steinsvik EK, Valeur J, Hausken T, Gilja OH Abstract Background/Aims: Dyspeptic symptoms are common in patients with functional gastrointestinal (GI) disorders, and may be related to visceral hypersensitivity. We aim to explore the relation between visceral hypersensitivity by using an ultrasonographic meal test and questionnaires in patients with irritable bowel syndrome (IBS) and/or functional dyspepsia (FD). Methods: Patients (FD, n = 94; IBS, n = 88; IBS + FD, n = 66, healthy controls [HC], n = 30) were recruited consecutively and examined with ultrasound of the proximal and distal stomach after dr...
This study investigated the effect of EA on IL-18 and gut microbial dysbiosis in one visceral hypersensitive rat models with PI-IBS. A trinitrobenzene sulfonic acid (TNBS)-induced visceral hypersensitivity rat model was developed. EA stimulation was applied to the ST25 and ST36 acupoints. Animals were assessed using abdominal withdrawal reflex (AWR) scores to determine the development of colonic visceral hypersensitivity. The 16S rRNA was used to correlate microbial diversity. IL-18 expression in colon was quantified by quantitative real-time PCR and western blotting. We identified that model rats had an increased visceral...
Condition: IBS - Irritable Bowel Syndrome Interventions: Drug: pentoxyifylline; Drug: Mebeverine; Drug: ethosuximide Sponsor: Tanta University Recruiting