Kruppel-like factor 4 improves obesity-related nephropathy through increasing mitochondrial biogenesis and activities.

In conclusions, the present findings firstly supported that renal KLF4 played an important role in combating obesity-related nephropathy, and KLF4/mitochondrial function partially determined the energy homeostasis in chronic kidney diseases.
PMID: 31800161 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - December 3, 2019 Category: Molecular Biology Authors: Jin L, Ye H, Pan M, Chen Y, Ye B, Zheng Y, Huang W, Pan S, Shi Z, Zhang J Tags: J Cell Mol Med Source Type: research