The high and lows of Type 2 asthma and mouse models

Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Superantigen-related CD4+ T cells were expanded in NPs and ethmoidal mucosal tissues from non-asthmatic CRSwNP patients and exhibited a potent Th2 cytokine-producing ability. In addition, their expansion was associated with disease extent in CRSwNP.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractAsthma is a heterogeneous disease, with the immune processes behind the chronic inflammation underlying this disorder differing between the various identified asthma endotypes. In addition to heterogeneity in underlying disease pathophysiology, asthmatics fall across a broad spectrum of disease severity and can vary greatly in their response to convention asthma therapies. A small percentage of patients with severe persistent asthma will remain uncontrolled despite treatment with high-dose inhaled corticosteroids and a long-acting beta-agonist. Less than two decades ago, there were few options for these treatment-r...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 23 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Cindy L.J. Weinstein, Nicholas Ryan, Xiaoli Zhang, Tulin Shekar, Davis Gates, Stephen J. Lane, Ioana Agache, Robert A. Nathan, SPIRO InvestigatorsAbstractBackgroundDue to historical safety concerns with use of long-acting beta agonists in asthma, step-down from inhaled corticosteroid/long-acting beta agonist (ICS/LABA) combination therapy to ICS monotherapy is recommended once asthma control is achieved.ObjectiveTo evaluate the benefit/risk question about whether asthma patients who achieve diseas...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 22 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Nicola A. Hanania, Ratko Djukanovic, Liam G. Heaney, Ming Yang, Bongin Yoo, Ahmar Iqbal, Noelle M. Griffin, Bradley E. Chipps
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsThe clinical phenotype of asthma that persists from childhood to adulthood seems to be a distinct phenotype of adult asthma.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Background Airway obstruction and wheezing in preschool children with recurrent viral infections are a major clinical problem, and are recognised as a risk factor for the development of chronic asthma. We aimed to analyse whether gene expression profiling provides evidence for pathways that delineate distinct groups of children with wheeze, and in combination with clinical information could contribute to diagnosis and prognosis of disease development. Methods We analysed leukocyte transcriptomes from preschool children (6 months–3 years) at acute wheeze (n=107), and at a revisit 2–3 months later...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and paediatrics Source Type: research
How does climate change threaten the health and survival of humans? Beyond obvious threats like heatstroke, doctors and other scientists suspect climate change factored in the 2012 Dallas epidemic of West Nile encephalitis and the spread of other tropical diseases shared by mosquitos. One physician expert points to climate change as a contributing factor for allergies, asthma, worse COPD conditions, and heart attacks. Physicians will address this timely issue and more during the 2020 Texas Medical Association (TMA) Winter Conference in Austin this week.
Source: TMA News Room - Category: Consumer Health News Source Type: news
ConclusionWe did not observe an increased risk of pregnancy losses or malformations among women with asthma. However, we found an association between asthma severity and SGA; and between exacerbations late in pregnancy and preterm delivery and NICU admission.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This article provides highlights of the clinically impactful original studies and reviews published in The Journal of Allergy and Clinical Immunology: In Practice in 2019 on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, food allergy, immunodeficiency, immunotherapy, rhinitis/sinusitis, and urticaria/angioedema/mast cell disorders. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization manageme...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ACUTE URTICARIA IN THE PAEDIATRIC EMERGENCY DEPARTMENT: MANAGEMENT AND POSSIBLE TRIGGERS. Ann Allergy Asthma Immunol. 2020 Jan 22;: Authors: Marques-Mejías MA, Tomás-Pérez M, Vilà-Nadal G, Quirce S PMID: 31981615 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
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