Sellar Region Extramedullary Plasmacytoma – A Rare Skull Base Tumour

Publication date: Available online 4 December 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Ho Yan Zheng, Senthil Kumar, Mohd Sofan ZenianAbstractPlasma cell neoplasms can present either as multiple myeloma, or in <10% of cases, as solitary plasmacytoma. Extramedullary plasmacytoma, a subtype of solitary plasmacytoma, only accounts for <5% of all plasma cell neoplasms, and <1% of all head and neck tumours. Extramedullary plasmacytoma usually arises from aerodigestive tract, and infrequently, from skull base and calvarium. Sellar region extramedullary plasmacytoma is a relatively rare tumour in the sellar region. Sellar region extramedullary plasmacytoma is usually asymptomatic until the lesion is large enough to impinge on surrounding structures, most commonly the cranial nerves. Radiological findings for extramedullary plasmacytoma are rather non-specific, but MR pituitary provides essential information with regards to its origin and its content, which aid in ruling out other diagnoses. The tumour usually enhanced homogenously post-Gadolinium, without involvement of surrounding bones. Due to the rarity of sellar region extramedullary plasmacytoma, tumour histo-pathological examination is recommended to achieve an accurate tissue diagnosis. Apart from neuroimaging, evaluations for plasma cell neoplasms include total body skeletal survey, serum and urine electrophoresis, routine blood count, serum calcium level and bone marrow biopsy. Principally, the diagno...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research