Anti-herpes simplex type-1 (HSV-1) activity from the roots of Jatropha multifida L

AbstractA new long chain, multifidione (1), together with seven known lathyrane-type diterpenes, 15-epi-4Z-jatrogrossidentadion (2), 4Z-jatrogrossidentadion (3), 2-epi-hydroxy isojatrogrossidentadion (4), 2-hydroxyisojatrogrossidentadion (5), 4E-jatrogrossidentadion (6), 15-epi-4E-jatrogrossidentadion (7), and jatrogrossidion (8), was isolated from the roots ofJatropha multifida L. The chemical structure of this new compound was elucidated by spectroscopic techniques. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated all compounds were evaluated for herpes simplex type-1 (HSV-1). Among them, compound6 showed the highest activity against HSV-1 (IC50 2.05  μg/mL), whereas the IC50 value of the standard drug, acyclovir, was 3.58  μg/mL. These results suggest that compound6 may has a potential target for anti-HSV-1 drug development.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research