A Case of Ventricular Fibrillation Induced by Takotsubo Syndrome with Congenital Long QT Syndrome.

A Case of Ventricular Fibrillation Induced by Takotsubo Syndrome with Congenital Long QT Syndrome. Intern Med. 2019 Nov 29;: Authors: Taguchi M, Sasa T, Izuhara M, Shioji K, Iwamuro A, Uegaito T, Matsuda M Abstract We herein report a case of congenital long QT syndrome (LQTS) in which the QT interval was prolonged by Takotsubo syndrome (TTS), inducing ventricular fibrillation (VF). The patient was a 55-year-old woman who had been diagnosed with LQTS. Cardiopulmonary arrest occurred while coughing during sleep. VF was observed, and her heartbeat returned after two defibrillations. An electrocardiogram showed marked QT prolongation and large negative T waves. Echocardiography demonstrated hyperkinesis at the base of the left ventricle and akinesis at the apex. As there was no significant stenosis in the coronary artery, she was diagnosed with TTS. PMID: 31787694 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research

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Conclusions: AED reliably identifies the underlying lethal ventricular arrhythmias in addition to aborting SCD.What is Known:•Although infrequent in children, sudden cardiac death (SCD) is often an unexpected and tragic event. The etiology is diverse and sometimes remains unknown despite extensive investigations.•Automated external defibrillator (AED) is both therapeutic in aborting SCD and diagnostic in identifying the underlying lethal ventricular arrhythmias. However, the diagnostic aspect of AED is under-acknowledged by most medical providers.What is New:•Four of 25 patients (16%) were initially managed ...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Conditions:   Long QT Syndrome;   Sleep Apnea Intervention:   Device: Continuous Positive Airway Pressure (CPAP) Sponsors:   The Cleveland Clinic;   MetroHealth Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: A combination of the longest QTc and autonomic imbalance during night-time sleep in early infancy may be responsible for development of life-threatening arrhythmia in LQTS infants. Critical cases should be included in future studies. PMID: 29952348 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
Human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium current (IKr) potassium channel, which is important for cardiac repolarization. Impairment of hERG function is the primary cause of acquired long QT syndrome, which predisposes individuals to cardiac arrhythmias and sudden death. Patients with hypoxia due to conditions such as cardiac ischemia or obstructive sleep apnea display increased incidence of cardiac arrhythmias and sudden death. We sought to understand the mechanisms that underlie hypoxia-associated cardiac arrhythmias. Using cell biology ...
Source: FASEB Journal - Category: Biology Authors: Tags: Research Source Type: research
Abstract: A 22-year-old female who was 10 weeks post-partum received successful resuscitation by her husband and defibrillation from QAS following out-of-hospital cardiac arrest during sleep with documented ventricular fibrillation. 12-lead ECG following arrest showed prolonged QTc 500ms. Echocardiography revealed mildly dilated left ventricle and moderate systolic dysfunction (EF 35-40%) with preserved basal function, which normalised within seven days. CT pulmonary angiogram, cardiac catheter study and cardiac MRI were normal.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 664 Source Type: research
Purpose of review: Provide evidence-based recent data on oral micronized progesterone (OMP) and progestins in menopausal hormonal therapy (MHT). Recent findings: Medroxyprogesterone acetate (MPA) increases breast cancer acting through the glucocorticoid receptor; progestins in MHT increase thrombosis more than oral estrogens; MPA, but not OMP or other progestins, increase monocyte cell endothelium adhesion; MPA and estradiol (E2)/MPA have negative brain effects, whereas E2/progesterone (P4) has neuroregenerative brain effects. The ‘window of opportunity’ cardiovascular disease hypothesis is not supported by a r...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: Reproductive Endocrinology Source Type: research
Publication date: December 2015 Source:Meta Gene, Volume 6 Author(s): Sameera Fatima Qureshi, Altaf Ali, Princy John, Amol P. Jadhav, Ananthapur Venkateshwari, Hygriv Rao, M.P. Jayakrishnan, Calambur Narasimhan, Jayaprakash Shenthar, Kumarasamy Thangaraj, Pratibha Nallari The SCN5A gene encodes for the INa channel implicated in long QT syndrome type-3 (LQTS-type-3). Clinical symptoms of this type are lethal as most patients had a sudden death during sleep. Screening of SCN5A in South Indian cohort by PCR-SSCP analyses revealed five polymorphisms — A29A (exon-2), H558R (exon-12), E1061E and S1074R (exon-1...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Conclusions— We conclude that intracellular Ca2+ contributes to the regulation of INaL conducted by NaV1.5 mutants and propose that, during excitation–contraction coupling, elevated intracellular Ca2+ suppresses mutant channel INaL and protects cells from delayed repolarization. These findings offer a plausible explanation for the lower arrhythmia risk in LQT3 subjects during fast heart rates.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrythmias-basic studies, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research
Conclusions:The presence and severity of obstructive sleep apnea (OSA) in patients with congenital long QT syndrome (LQTS) is associated with increased QT prolongation corrected for heart rate, which is an important biomarker of sudden cardiac death (SCD). Treatment of OSA in LQTS patients may reduce QT prolongation, thus reducing the risk of LQT-triggered SCD.Citation:Shamsuzzaman AS, Somers VK, Knilans TK, Ackerman MJ, Wang Y, Amin RS. Obstructive sleep apnea in patients with congenital long QT syndrome: implications for increased risk of sudden cardiac death. SLEEP 2015;38(7):1113–1119.
Source: Sleep - Category: Sleep Medicine Source Type: research
Conclusions All 20 patients with LQTS were mostly symptomatic at presentation. Owing to the geographical region and ethnicity of the Thai population, we conclude that the ratio of patients who develop cardiac symptoms at rest or during sleep might be higher than in other Asian countries.
Source: Journal of Arrhythmia - Category: Cardiology Source Type: research
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