New protein function could be key to treatment of drug addiction and behavioral disorders

(Nagoya University) The reward pathway of the brain causes feelings of happiness but is also involved in behavioral disorders like schizophrenia and addiction. A breakthrough study by scientists in Japan has now identified the role of a protein called Npas4 in the reward pathway, mediated by the well-known proteins MAPK and CBP, opening doors to potential therapies for associated disorders. Cocaine-treated mice with inactivated Npas4 exhibited considerable reduction in cocaine-seeking behavior, emphasizing the relevance of the protein.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 16 January 2020Source: Neuroscience ResearchAuthor(s): Yuichi Takeuchi, Antal BerényiAbstractOscillatory brain activities support many physiological functions from motor control to cognition. Disruptions of the normal oscillatory brain activities are commonly observed in neurological and psychiatric disorders including epilepsy, Parkinson’s disease, Alzheimer’s disease, schizophrenia, anxiety/trauma-related disorders, major depressive disorders, and drug addiction. Therefore, these disorders can be considered as common oscillation defects despite having distinct behavio...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
__________ We are pleased to share a fantastic professional development opportunity offered by the Luria Neuroscience Institute and featuring renowned neuropsychologist Elkhonon Goldberg, Ph.D., ABPP. Inaugural 5‑day Goldberg Brain-Mind Symposium (February 17–21st, 2020): Dr. Goldberg has been a frequent visitor to Bali for 30 years and is currently engaged in cross-cultural neuroscience research with two major Indonesian universities. He personally designed this unique and comprehensive event to discuss cutting edge cognitive neuroscience and state-of-the-art clinical insights with a small group of participants in...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Professional Development Bali discount code Elkhonon-Goldberg Executive-Functions frontal-lobes Goldberg Brain-Mind Symposia Luria Neuroscience Institute neuropsychologist webinar sequence Source Type: blogs
  Sex addict. Nympho. You’ve likely heard these words used for a person with hypersexuality, but what exactly is this condition? Is hypersexuality really a symptom of a mental disorder or is it just a super high libido? Where does one draw the line between liking (or loving) sex and being hypersexual? Is it similar to a drug addiction? Or a binge eating disorder?  Join Gabe and Jackie as they tackle this often misunderstood topic and hear Gabe’s own personal experiences with hypersexuality as a debilitating symptom of his bipolar disorder. (Transcript Available Below) SUBSCRIBE &REVIEW About Th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Not Crazy Podcast Relationships Sexuality Source Type: blogs
Alcohol is a dangerous substance. It is addictive, can deteriorate one’s health, and puts innocent people in danger. However, it is embraced and celebrated in society and there are many opportunities throughout life to try alcohol. Knowing that alcohol is dangerous and addictive can leave many people wondering, “why do people drink alcohol?” Soothe an Underlying Mental Health Condition One of the major reasons that individuals who suffer from alcohol use disorder drink are because they are suffering from an underlying mental health condition and are using alcohol to self-medicate. This condition can be e...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol treatment alcohol treatment center Source Type: blogs
One of the new trends on social media is “dopamine fasting,” the idea that depriving yourself is somehow good for you.  Is it? Does this trend have any benefit? Could it even be harmful? What’s the science behind it? On today’s episode, Gabe welcomes back Psych Central founder and editor-in-chief, Dr. John Grohol.  Join us as Dr. John gives us the 411 on dopamine fasting. SUBSCRIBE &REVIEW Guest information for ‘Dr. John Grohol Dopamine’ Podcast Episode John M. Grohol, Psy.D. is a pioneer in online mental health and psychology. Recognizing the educational and social pot...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Interview Podcast Psychiatry The Psych Central Show Source Type: blogs
In this study, we investigated whether polymorphisms in miRNAs are associated with MA disorder with psychosis.MethodsWe carried out a case-control association study in 400 MA users with psychotic characters and 448 controls. Six MiRSNPs with predicted functional relevance miRNAs (miR-181b, miR-181a, miR-15b, miR-let-7e and miRlet-7d) were selected for genotyping. Allele and genotype frequencies were compared between MA users and healthy individuals. The expression of five miRNAs were measured by quantitative real-time RT-PCR in 55 cases and 57 controls. We also explored an expression Quantitative Trait Loci (eQTL) analysis...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AbstractNINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer ’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While theNINJ2 rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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Source: Journal of Addictive Diseases - Category: Addiction Authors: Source Type: research
This study aimed to examine whether clinicians in community managed mental health organisations hold attitudes and beliefs that could be considered stigmatising towards clients with a dual diagnosis (ddx). Using an online survey, mental health clinicians (n = 32) were presented with three vignettes depicting a person with (1) schizophrenia, (2) schizophrenia and alcohol dependence and (3) schizophrenia and methamphetamine use, and two scales measuring stigmatising attitudes. Scores across the vignettes were compared to assess attitudes towards dual diagnosis compared to mental illness. Mental health clinicians' responses s...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
Dana Carpender, friend and author of many low-carb cookbooks, provided this review of my new Revised &Expanded Wheat Belly, below. For more of Dana’s signature wit and conversation, you can join her on her engaging Facebook page “Hold the toast press” or visit her Amazon page that lists all her wonderful low-carb cookbooks. It’s funny how things happen. Nine years ago I had already been eating a low carbohydrate diet for 16 years. During that time I had occasionally eaten low carb tortillas and low carb bread. These things were hardly a staple of my diet, but I kept ’em around for the occ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune joint pain wheat belly Source Type: blogs
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