Long-term benefit from immune modulation and anti-inflammatory treatment in metastatic mesothelioma.

Long-term benefit from immune modulation and anti-inflammatory treatment in metastatic mesothelioma. Respir Med Case Rep. 2020;29:100971 Authors: Dalgleish AG, McLean E, Patel N, Rahman N Abstract A 64 year old male heating engineer was investigated for a persistent cough and found to have epithelioid mesothelioma with pleural effusion, lung nodules and increased thoracic lymph nodes. He declined standard of care treatment following his own research and he was enrolled in a named patient programme of IMM-101. He was advised to correct his low vitamin D3 level and to start using anti-inflammatories such as aspirin, bromelain and low dose Naltrexone. At review one year later a CT scan showed no change and he continued on the regimen. Four years after the diagnosis a CT scan showed that there was a modest but definite progression of the left malignant pleural thickening, and a new right-sided effusion, enlargement of several intrathoracic nodes which had been noted on the early scans. The chest wall lump eventually broke down and required local radiotherapy. He then developed abdominal pain and found to have peritoneal disease. Last year he obtained the cannabinoids CBD and THC which slowed down the disease and a CT scan after he had been on this for six months, showed that his disease was fairly stable with marginal progression. PMID: 31788420 [PubMed]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Case Rep Source Type: research

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Publication date: Available online 21 November 2019Source: Respiratory Medicine Case ReportsAuthor(s): Angus G. Dalgleish, Emma Mc Lean, Nirav Patel, Najib RahmanAbstractA 64 year old male heating engineer was investigated for a persistent cough and found to have epithelioid mesothelioma with pleural effusion, lung nodules and increased thoracic lymph nodes. He declined standard of care treatment following his own research and he was enrolled as a named patient programme of IMM-101-015. He was advised to correct his low vitamin D3 level and to start using anti-inflammatories such as aspirin, bromelain and low dose Naltrexo...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). With the suspicious of a pleural mesothelioma, a CT-scan before and a18F-FDG PET/CT-scan later were performed revealing multiple pleural thickenings and multiple mediastinal lymphadenopathies with radiotracer uptake. EBUS-TBNA EBUS-TBNA did not resul...
Source: Lung - Category: Respiratory Medicine Source Type: research
Publication date: Available online 7 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Munir Ahmad, Muhammad Omer Aamir, Khurram Minhas, Khwaja Ajmal, Iftikhar AhmadAbstractMalignant pleural mesothelioma (MPM) is a rare and highly aggressive intrathoracic neoplasm that typically offer poor prognosis. In general, development of MPM is linked with a history of asbestos exposure. Herein we report a 56-year-old female patient with MPM, who presented with complains of chest pain, cough, shortness of breath and weight loss. The patient’s radiological work-up demonstrated right sided plural effusion ...
Source: Egyptian Journal of Basic and Applied Sciences - Category: Science Source Type: research
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A 31-year-old male with no past medical history and no occupational risk factors presented to the emergency department complaining of cough, fever, and right pleuritic chest pain. Chest radiograph showed opacification of the right hemithorax. Thoracic computed tomography (CT) showed a large heterogeneous pleural mass occupying the entire right hemithorax (Fig). A CT-guided core needle biopsy confirmed a sarcomatoid mesothelioma.
Source: Surgery - Category: Surgery Authors: Source Type: research
Authors: Nakamura K, Nakayama K, Nagaoka R, Nishisako K, Ishikawa M, Katagiri H, Ishibashi T, Sato E, Amano C, Kyo S Abstract Malignant peritoneal mesotheliomas (MPMs) are rare and progressive tumors, which may present similarly to primary peritoneal carcinoma or ovarian carcinoma (OC). The current study reports two cases of MPM that initially presented with the features of OC, for which paired box 8 (PAX8) immunostaining was found to be useful for diagnosis. The two patients were women, aged 58 and 56 years, respectively. The primary presenting symptoms and clinical findings included prolonged abdominal pain, abdo...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusions. The mean age of the patients was 63 years, and the male to female ratio 1.7:1. Approximately 58% had exposure to asbestos, and 73% had a smoking history; familiarity was rarely reported. The most common anatomical site of origin was the right pleura, and the most frequent clinical manifestation were chest pain, dyspnea, cough, and weight loss. Thoracic X‐ray and computed tomography were the imaging techniques most employed for diagnosis and surgical planning. The pathological diagnosis was obtained by examination of surgical or biopsy specimens in most cases. The best treatment strategy of deciduoid mesothel...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
Abstract Limited biomarkers predicting prognosis of malignant pleural mesothelioma (MPM) have been identified. The present study aims to assess potential laboratory prognostic factors of MPM. We retrospectively reviewed the clinical data of 105 patients with MPM. The overall survival and prognostic factors were assessed by Kaplan-Meier curves and Cox regression analysis. A receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off values. The mean age of the 105 patients (62 men, 43 women) was 56.0 years. The major clinical presentations were dyspnea, cough and chest pain...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
Management of malignant pleural mesothelioma - part 1: epidemiology, diagnosis, and staging : Consensus of the Austrian Mesothelioma Interest Group (AMIG). Wien Klin Wochenschr. 2016 Sep 12; Authors: Geltner C, Errhalt P, Baumgartner B, Ambrosch G, Machan B, Eckmayr J, Klikovits T, Hoda MA, Popper H, Klepetko W, Austrian Mesothelioma Interest Group (AMIG) Abstract Malignant pleural mesothelioma is a rare malignant disease that in the majority of cases is associated with asbestos exposure. The incidence in Europe is about 20 per million inhabitants and it is increasing worldwide. Initial...
Source: Wiener Klinische Wochenschrift - Category: Journals (General) Authors: Tags: Wien Klin Wochenschr Source Type: research
Authors: Mercadante S, Degiovanni D, Casuccio A Abstract CONTEXT: Mesothelioma is a very aggressive cancer that is brought on by asbestos exposure. Because there is a long latency period between exposure to asbestos and symptoms of disease, most patients with mesothelioma present with advanced disease and survive an average of 8-12 months. Thus, best supportive care should be considered critical to optimally manage these patients. AIM: The aim of this study was to examine the epidemiological characteristics and symptom burden of mesothelioma patients when admitted to home palliative care. METHODS: The chart...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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