Evolution of secondary hyperparathyroidism in patients following return to hemodialysis after kidney transplant failure.

Evolution of secondary hyperparathyroidism in patients following return to hemodialysis after kidney transplant failure. Nephrol Ther. 2019 Nov 29;: Authors: Jannot M, Normand M, Chabroux-Seffert A, Azzouz L, Afiani A, Jurine J, Ziane A, Mariat C, Lafage-Proust MH Abstract INTRODUCTION: Severe uncontrolled secondary hyperparathyroidism and kidney transplantation history are both risk factors for fractures in hemodialyzed patients. Moreover, patients who return to dialysis after transplant failure have more severe infections/anemia and higher mortality risk than transplant-naive patients starting dialysis with native kidneys. In this context, our aim was to test the hypothesis that transplant failure patients have more secondary hyperparathyroidism than transplant-naive patients. METHODS: We retrospectively compared 29 transplant failure patients to 58 transplant-naive patients matched for age, sex, chronic kidney disease duration and diabetes condition (1 transplant failure/2 transplant-naive ratio), who started dialysis between 2010 and 2014. Clinical and biological data were collected at baseline, 6 and 12 months. FINDINGS: At baseline, neither serum parathyroid hormone (transplant-naive: 386±286pg/mL; transplant failure: 547±652pg/mL) nor serum 25-hydroxyvitamin D (transplant-naive: 27.8±17.0μg/L, transplant failure: 31.1±14.9μg/L) differed between groups. However, serum parathyroid ...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research

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