Comparative pharmacokinetics of quercitrin, astragalin, afzelin, and taxifolin in plasma after oral administration of Polygonum orientaleinflorescence in sham-operated and myocardial ischemia-reperfusion injury rats.

Comparative pharmacokinetics of quercitrin, astragalin, afzelin, and taxifolin in plasma after oral administration of Polygonum orientaleinflorescence in sham-operated and myocardial ischemia-reperfusion injury rats. Xenobiotica. 2019 Dec 02;:1-31 Authors: Zheng L, Li Y, Zhou Z, Xiang W, Gong Z, Chen S, Wang Y, Wang A, Lan Y, Li Y, Huang Y Abstract The study aimed to compare the pharmacokinetic properties of quercitrin, astragalin, afzelin, and taxifolin, four major bioactive components of Polygonum orientale inflorescence extracts, between sham-operated and myocardial ischemia-reperfusion injury (MIRI) rats. Rats were divided into two groups: MIRI model and sham-operated. The blood samples were collected according to the time schedule. The levels of quercitrin, astragalin. afzelin, and taxifolin in the plasma at designated time points were determined using an HPLC-MS/MS method. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods. After the administration of the Chinese herb Polygonum orientale inflorescence extracts, the Cmax, AUC, as well as MRT, increased, while CL decreased, in MIRI model compared to the sham-operated animals. These results suggest that the pathological damage of ischemia-reperfusion had a significant impact on the pharmacological effects of Polygonum orientale inflorescence extracts on ischemic heart disease. The method had been success...
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research