Taming chronic inflammation may reduce illness, save lives

Scientists from 22 institutions, including UCLA, are recommending early diagnosis, prevention and treatment of severe chronic inflammation to reduce the risk of chronic disease and death worldwide.The group of international experts, which also includes scientists from the National Institutes of Health, Stanford University, Harvard Medical School, Columbia University Medical Center and University College London, point to inflammation-related diseases as the cause of 50 percent of all deaths worldwide.Inflammation is a naturally occurring response by the body ’s immune system that helps fight illness and infection. When inflammation is chronic, however, it increases the risk of developing potentially deadly diseases. Ina perspective article, published in the journal  Nature Medicine, the authors describe how persistent and severe inflammation in the body plays a key role in heart disease, cancer, diabetes, kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodegenerative disorders.Future research should focus on identifying ways to better diagnose and treat severe chronic inflammation, according to the authors. Doing so may not only extend life, but also help reduce chronic disease worldwide and improve health, they said.Senior author  George Slavich, director of the  UCLA Laboratory for Stress Assessment and Research, said it is important to make people aware of the risk factors for chronic inflammation, which include obesity, ph...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Authors: Teng M, Zhou S, Cai C, Lupien M, He HH Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American men. While androgen deprivation has remained as the cornerstone of prostate cancer treatment, resistance ensues leading to lethal disease. Forkhead box A1 (FOXA1) encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors. Through direct interactions with the Androgen Receptor (AR), FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells. FOXA1 also possesse...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Hi all, I've been having a lot of anxiety regarding a critical decision I made several years prior. When I was a senior in high school, I received admission to a school that now ranks among the Top 3 public universities in the United States. Although I did receive a small scholarship (several thousand), it would have put me into significant debt. I instead opted for a much smaller school (which ranks between 150-200) that was generous enough to endow me with a full-tuition merit... Dealing with Anxiety as a Pre-Med
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AbstractPurposeTo evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs).Materials and methodsThis retrospective comparative study includes 29 eyes with DME (Group 1) and 43 eyes with DME and ERM (Group 2). After three consecutive monthly 2.0  mg IAIs, subjects received monthly follow-ups and retreatment was performed if needed. Corrected visual acuity (CVA), central macular thickness (CMT), and central macular volume (CMV) parameters were recorded tri-monthly, and the ...
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Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
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