Enhanced Population-based Core Surveillance of Meningococcal Invasive Infections at Participating Centers Across Canada

Condition:   Invasive Meningococcal Disease Intervention:   Other: surveillance Sponsors:   Canadian Paediatric Society;   Pfizer;   GlaxoSmithKline Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We describe here a young immuncompetent adult of Indian origin from Ghana, West Africa with cryptococcal meningitis who had several ups and downs during his treatment. First he developed neurologic worsening due to premature transition from intensive to consolidation phase therapy. Subsequently he deteriorated due to “immune reconstitution inflammatory syndrome (IRIS)” like phenomenon that necessitated the prolonged use of steroids. Additionally he suffered serious adverse effects due to antifungal drugs including liposomal amphotericin B and flucytosine. He recovered after 16 months of treatment. The case high...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Kye Vincent, of Leighton Buzzard, Bedfordshire, was given days to live in April 2016 when he was struck down with the killer infection.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We thank Dr. Jolobe for his insightful comments regarding our review “Tuberculosis: a focused review for the emergency medicine clinician” [1,2]. Dr. Jolobe highlighted several conditions that present similarly to tuberculosis (TB), including pleural effusion in a patient with previously diagnosed rheumatoid arthritis and systemic lupus erythematosus, pericardial effusion in a patient with previously diagnosed rheumatoid arthritis and systemic lupus erythematosus, immunoglobulin G4-related pleuropulmonary disease and tuberculous pleurisy, and disseminated tuberculosis in a patient with cryptococcal meningitis [1].
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Opisthotonos, extreme involuntary neck and back extension, is rarely seen in modern emergency departments. Vaccines have prevented the most common causes of this clinical presentation. Alternatively, otitis media is one of the most common pediatric infections and is characteristically non-invasive and harmless. In exceedingly rare cases, otitis media can develop complications and progress to invasive pneumococcal diseases including mastoiditis and meningitis. Streptococcus pneumoniae accounts for the majority of otitis media infections, however, since the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) a...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Conclusion: The diagnostic formula developed in the present study can help physicians to differentiate tuberculous meningitis from bacterial meningitis in high-tuberculosis-incidence-areas, particularly in settings with limited microbiological and radiological resources.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
We present 3 cases of recurrent pneumococcal meningitis where detailed neuro-imaging revealed subtle anterior base of skull defects not detected on initial investigations.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Instructive Cases Source Type: research
We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal flu...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractPurpose of the ReviewThe purpose of this review is to summarize and evaluate relevant literature on combination antifungal therapy for invasive fungal infections (IFIs).Recent FindingsCryptococcal meningitis has the largest body and highest quality in support of combination therapy with amphotericin B and flucytosine. More recent data in treatment of invasive aspergillosis suggest combination therapy with voriconazole and echinocandins may be effective in select patients. Quality studies are needed to define combination therapy in rare mold infections.SummaryMultiple strategies have been employed to optimize treatm...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Authors: Zintgraff J, Fossati S, Pereira CS, Veliz O, Regueira M, Moscoloni MA, Irazu L, Lara C, Napoli D, Argentina Spn Working Group Abstract Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. To identify the serotypes most commonly associated with infection in adults in Argentina, 791 pneumococcal isolates from 56 hospitals belonging to 16 provinces and Buenos Aires city were serotyped. The isolates were submitted as part of a National Surveillance Program for invasive pneumococcal disease in adults, which started in 2013. Serotypes 3, 8, ...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
This report presents a 36-year-old female admitted to a tertiary university hospital with a primary complaint of intractable headache, caused by a combination of Medication Overuse Headache (MOH), and headache secondary to aseptic meningitis. During her hospital stay, opioid analgesic doses were initially increased without success in an attempt to control her headache. Despite multiple medication trials the patient’s headache failed to improve. On day ten of her hospitalization, she underwent a thirty-minute acupuncture session which resulted in immediate relief of her headache. She received one more acupuncture trea...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
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