Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population
Conditions: Acute Myocardial Infarction; Non-Obstructive Coronary Atherosclerosis; Ischemic Heart Disease; Angina Pectoris; Coronary Microvascular Disease Interventions: Other: MINOCA registry; Diagnostic Test: CCTA Phenotypes Sponsor: AHEPA University Hospital Not yet recruiting
This report provides 2017-2018 U.S. hypertension prevalence estimates using the 2017 American College of Cardiology and American Heart Association definition of hypertension (3) and new guidelines, which redefine hypertension by lowering the previous threshold levels of 140/90 mmHg to 130/80 mmHg (4). This change categorizes a greater percentage of people as having hypertension. PMID: 32487290 [PubMed - in process]
CONCLUSIONS: The 3-year follow-up of the TARGET All Comers study showed comparable safety and efficacy profiles of the biodegradable polymer Firehawk and the durable polymer XIENCE stent. PMID: 32482617 [PubMed - as supplied by publisher]
CONCLUSIONS: Ticagrelor monotherapy after 1-month DAPT provided consistent treatment effects on ischemic endpoints in patients with or without ACS but only the former experienced a net clinical benefit. Trial registration ClinicalTrials.gov number NCT03231059. PMID: 32482616 [PubMed - as supplied by publisher]
CONCLUSIONS: Despite modern advances in screening, management, and interventional measures for CVD, rising trends in CVD risk factors across all sex and race/ethnic groups call for attention by preventive cardiologists. PMID: 32483642 [PubMed - in process]
The coronavirus disease 2019 (COVID-19), seems to have a cardiovascular tropism characterized by high incidence of myocardial infarction especially for patients with severe infections recovered in intensive care units. In their letter, the Authors state that oxidative stress could play a pivotal role to determine cardiovascular complications in COVID-19. We agree about this issue. In particular, NADPH oxidase-2 (NOX-2), that it is considered one of the most important sources of superoxide anion in human , plays a role in systemic inflammation and pathogenesis of several RNA virus as the influenza virus .
We have read an experimental study entitled “miR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway” written by Li and his colleagues . They demonstrated that miR-135b overexpression remarkably restored impaired cardiac function caused by myocardial infarction(MI)via restraining pyroptos is pathway.
Recently, we have read with great interest Dr. Zhao and colleagues' article entitled “Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction”  that published in International Journal of Cardiology. In this article, they draw a conclusion that the concentrations of serpina3 prospectively predict the development of major adve rse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Conclusions. LDL-C is the lipid fraction strongest associated with younger age of presentation of first MI. These results support the importance of controlling and treating LDL-C in prevention of premature MI. PMID: 32483990 [PubMed - as supplied by publisher]
In this report, we demonstrate that collagen V, a fibrillar collagen and a minor constituent of heart scars regulates the size of heart scars after ischemic cardiac injury. Depletion of collagen V in heart scars in two independent animal models led to a significant and paradoxical increase in post infarction scar tissue size with worsening of heart function. A systems genetics approach analyzing genes versus traits across 100 in-bred strains of mice independently demonstrated that collagen V is a critical driver of post injury heart function. We show that collagen V deficiency alters the ultra-structure and mechanical prop...
ConclusionRobotically assisted Heller myotomy and POEM are safe and efficacious treatments for achalasia with lower rates of technical complications compared to laparoscopic Heller myotomy. With the advancements in endoscopic instruments and robotic surgery, POEM and robotically assisted Heller myotomy should be considered in the treatment of achalasia and esophageal dysmotility disorders.