Use of Fresh Leukocyte-rich Platelet Rich Plasma or Fresh Leukocyte-poor Platelet Rich Plasma for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
Condition: Osteoarthritis, Knee Interventions: Other: Fresh Platelet Rich Plasma with leukocyte; Other: Fresh Platelet Rich Plasma without leukocyte Sponsor: Istituto Ortopedico Rizzoli Not yet recruiting
Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage. Eur Cell Mater. 2020 Jan 15;39:65-76 Authors: Alaqeel M, Grant MP, Epure LM, Salem O, AlShaer A, Huk OL, Bergeron SG, Zukor DJ, Kc R, Im HJ, Anbazhagan AN, Antoniou J, Mwale F Abstract Osteoarthritis (OA) is a disease of diarthrodial joints associated with extracellular matrix proteolytic degradation under inflammatory conditions, pain and disability. Currently, there is no therapy to prevent, reverse or modulate the disease course. The present study aimed at evaluating the regenerative potential of Link...
Authors: Kotelsky A, Carrier JS, Aggouras A, Richards MS, Buckley MR Abstract Chondrocytes, the resident cells in articular cartilage, carry the burden of producing and maintaining the extracellular matrix (ECM). However, as these cells have a low proliferative capacity and are not readily replaced, chondrocyte death due to extreme forces may contribute to the pathogenesis of osteoarthritis (OA) after injury or may inhibit healing after osteochondral transplantation, a restorative procedure for damaged cartilage that requires a series of mechanical impacts to insert the graft. Consequently, there is a need to under...
In conclusion, although the incidence of heterotopic ossification after TAA is considerable, there is insufficient literature to suggest that heterotopic ossification after TAA impacts range of motion or functional outcome.
Authors: Gu Y, Ren K, Jiang C, Wang L, Yao Q Abstract This present study aims to verify the underlying mechanism that anti-aging protein Klotho protects cartilages against the damage induced by oxidative stress. The Klotho expression level in the articular cartilages of mice with osteoarthritis (OA) was measured by using western blotting and quantitative real-time PCR. This work also investigated the effects of Klotho on chondrocyte functions, such as PI3K/Akt pathway, apoptosis and reactive oxygen species (ROS) production, through overexpressing Klotho in chondrocytes by transfecting with the plasmid encoding Klot...
Conclusion: For elderly women with knee osteoarthritis, knee muscle strength decreases significantly, especially for the extensor strength. Moreover, compared with fat mass, the index of muscle mass is more sensitive in detecting the decrease in knee joint torque. Therefore, rather than weight loss alone, the quadriceps muscle and the rear-thigh muscles, which maintain the stability of knee joints during rehabilitation training, should be strengthened emphatically to improve muscle mass.
The relationship between obesity and glenohumeral osteoarthritis is relatively understudied. The purpose of this study was to better define this relationship by age- and gender-matching 596,874 patients across six body mass index (BMI) cohorts and determining the prevalence of glenohumeral osteoarthritis and the standardized rate of glenohumeral arthroplasty in each cohort. Individuals with a BMI over 24 were found to be at increased odds for developing glenohumeral osteoarthritis, compared to the normal BMI cohort, and individuals with a BMI over 30 were additionally found to be at increased odds for undergoing glenohumeral arthroplasty.
In this review article, the authors present the many challenges that orthopedic surgeons in developing countries face when implementing arthroplasty programs. The issues of cost, sterility, and patient demographics are specifically addressed. Despite the many challenges, developing countries are beginning to offer hip and knee reconstructive surgery to respond to the increasing demand for such elective operations as the prevalence of osteoarthritis continues to increase. The authors shed light on these nascent arthroplasty programs.
Nature Reviews Rheumatology, Published online: 16 January 2020; doi:10.1038/s41584-020-0369-5Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.
Few patients with knee osteoarthritis receive the elective surgery within 2 years, a study found; delays were more common among African Americans.Medscape Medical News