Shares of Cambridge biotech plunge as postpartum drug fails late-stage trial

One of the biotech industry ’s emerging neuroscience companies, Sage Therapeutics, disclosed Thursday that one of its most promising potential products failed a late-stage study. The Cambridge-company's shares fell by more than half on Thursday morning, shaving more than $3 billion off its market value. Sage (Nasdaq: SAGE) has become one of the area biotech industry’s most closely watched companies through its work on postpartum depression and other psychiatric disorders. It has consistently…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Maternal postpartum depression (PPD) is a risk for disruption of mother-infant interaction. Infants of depressed mothers have been found to display less positive, more negative, and neutral affect. Other studies have found that infants of mothers with PPD ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Conclusions: ELS-induced visceral pain and visceral hypersensitivity are associated with the underfunction of SK2 channels in the spinal DH. PMID: 33029124 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Publication date: Available online 8 October 2020Source: Brain, Behavior, and ImmunityAuthor(s): Abdulla A-B Badawy
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Authors: Chalise M, Karmacharya I, Kaphle M, Wagle A, Chand N, Adhikari L Abstract Postnatal depression is linked with adverse outcomes for mothers, offspring, and her entire family, which stands as a significant public health problem and is often taken as a neglected issue of maternal and child health in the developing world. Postnatal depression is often falsely interpreted as common consequences related to the recent delivery. The main objective of this study is to find out the status of postnatal depression and the factors associated with it among the postnatal mothers attending at Bharatpur Hospital. Methodolo...
Source: Depression Research and Treatment - Category: Psychiatry Tags: Depress Res Treat Source Type: research
Authors: Ayoub K, Shaheen A, Hajat S Abstract Background: Postpartum Depression (PPD) is a major public health problem affecting mothers and their babies. However, few studies have investigated the prevalence and risk factors for postpartum depression among Arab mothers. This systematic literature review aims to determine the prevalence of PPD among mothers in Arab countries and identify the main risk factors. Methods: A review of all peer-reviewed journal published studies on PPD and its risk factors among Arab mothers until February 2016. The following data bases were searched; PubMed, Springlink, Science dir...
Source: Clinical Practice and Epidemiology in Mental Health - Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research
Condition:   Postpartum Depression Intervention:   Behavioral: Group Interpersonal Psychotherapy Sponsors:   McMaster University;   Hamilton Academic Health Sciences Organization Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This paper studies the effect of maternal depression on early childhood cognition in Peru, where rates of depression are around 50%. By using an instrumental variables approach, this study exploits variation in the exogeneity of the exposure to shocks duri...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Condition:   Postpartum Depression Intervention:   Behavioral: Group Interpersonal Psychotherapy Sponsors:   McMaster University;   Hamilton Academic Health Sciences Organization Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The rising maternal mortality rate has drawn increased focus to postpartum depression. However, other mental health conditions, such as birth-related postpartum traumatic stress disorder, have not garnered the same level of attention. The majority of research about postpartum posttraumatic stress disorder (PTSD) is published in journals focused on psychiatry, psychology, and nursing, where this phenomenon is well recognized. In contrast, there is a lack of awareness among most obstetricians. Consequently, few recommendations are available to guide clinical practice. This commentary will present a clinical...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
CONCLUSION: It is argued that a broad umbrella construct of 'the conflicted mother' exists in PND experience. This study highlights the importance of the mother's own maternal relationship in living with depression. The authors discuss limitations of the study, make service recommendations to improve current clinical practice for women with PND, and provide future research directions. PMID: 33019805 [PubMed - as supplied by publisher]
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
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