Shares of Cambridge biotech plunge as postpartum drug fails late-stage trial

One of the biotech industry ’s emerging neuroscience companies, Sage Therapeutics, disclosed Thursday that one of its most promising potential products failed a late-stage study. The Cambridge-company's shares fell by more than half on Thursday morning, shaving more than $3 billion off its market value. Sage (Nasdaq: SAGE) has become one of the area biotech industry’s most closely watched companies through its work on postpartum depression and other psychiatric disorders. It has consistently…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Wassif OM, Abdo AS, Elawady MA, Abd Elmaksoud AE, Eldesouky RS Abstract Postpartum depression (PPD) is a mood disorder that begins after childbirth and usually lasts beyond six weeks; depression is often comorbid with anxiety. The main objectives of this work were to measure the prevalence of postpartum depression and/or anxiety among females in the Qaliubeya governorate to explore the underlying factors of these disorders and find if progesterone level has a role. A crosssectional study was conducted upon 500 postpartum females attending primary health care facilities in the Qaliubeya governorate. Data we...
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
Previous observational epidemiological studies have reported inconsistent findings regarding the association between anemia and the risk of maternal depression. In the present study, we investigated the relationship between anemia and the risk of maternal ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
BACKGROUND: Traditional postpartum practices are intended to provide care to mothers, but there is mixed evidence concerning their impact on postpartum depression (PPD). It remains unknown if there is a unique impact of postpartum practices on PPD separate...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
ConclusionMS-combined CUMS could develop depression-like behavior in adult. SNS exhibited antidepressive effects accompanied by improving synaptic plasticity by activation of the CaSR-PKC-ERK signaling pathway.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: May 2020Source: Neurobiology of Stress, Volume 12Author(s): Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. LambertAbstractIn the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peripheral endocrine glands, but locally in the central nervous system (CNS), to potentially act as paracrine, or autocrine “neurosteroid” messengers, thereby fine tuning ne...
Source: Neurobiology of Stress - Category: Neuroscience Source Type: research
Appropriate early recognition and timely treatment of postnatal depression is essential if patients are to make a full recovery.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
 Touch is a powerful thing. From the time we’re born, and throughout our lives, humans need touch to thrive and develop properly. Sadly, many people in our culture experience a profound lack of caring and respectful platonic touch. Today’s guest, Rev. Edie Weinstein, has a remedy for this. She is the founder of Hug Mobsters Armed With Love, which offers FREE HUGS events for the public. Tune in to discover how Edie got started in the hugging “business,” the ins and outs of giving free hugs in public, and how she manages to gently navigate our culture’s understandable wariness of inappropria...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Inspiration & Hope Interview Mental Health and Wellness Podcast The Psych Central Show Source Type: blogs
Abstract The purpose of this study was to investigate the effect of iodine supplementation during pregnancy on thyroid function and also its effect on postpartum depression in an iodine-sufficient area. Healthy pregnant women were divided into three groups: group A (vitamin iodine-150) receiving vitamin containing 150 μg iodine, group B (vitamin iodine-0) receiving vitamin without iodine, and group C (no vitamin) receiving no vitamin. General information was collected by questionnaire and thyroid function was determined in the third trimester of pregnancy. Depression was assessed 1 month postpartum by...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
AbstractPregnant African American women who report higher levels of social disorder (e.g., vacant housing, drug dealing) in their neighborhoods also report higher levels of depressive symptoms. The effects of social disorder in the neighborhood during childhood on depressive symptoms during pregnancy are not known. Also unknown is the interaction between social disorders in the neighborhood during childhood and during pregnancy regarding depressive symptoms during pregnancy. The purpose of this study was to examine whether higher levels of social disorder in the neighborhood during pregnancy buffered the association of soc...
Source: Journal of Urban Health - Category: Health Management Source Type: research
Stress, anxiety, depression more prevalent among women carrying fetuses with congenital heart disease
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Family Medicine, Gynecology, Neurology, Pathology, Pediatrics, Psychiatry, Radiology, Journal, Source Type: news
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