Is hip osteoarthritis preventable?

Publication date: Available online 4 December 2019Source: Joint Bone SpineAuthor(s): Alice Courties, Francis BerenbaumAbstractOne quarter of 45-year-old adults will develop symptomatic hip osteoarthritis (OA). Therefore, hip OA affects a very significant number of patients and, together with knee OA, is associated with increased cardiovascular mortality. Primary prevention involves the identification and management of its modifiable risk factors. Those that we know of today include anatomical abnormalities, joint trauma, certain occupations and, to a lesser extent, obesity. Screening for hip dysplasia as early as possible, the prevention of sports-related joint injuries by the use of warm-up exercises and moderate physical activity such as running have demonstrated a certain degree of efficacy in the prevention of hip OA, although the data for this come from low quality studies. The effect of weight loss, while intuitive and effective in preventing knee OA, has not been studied as a preventive measure in hip OA, although there is a symptomatic effect in the case of confirmed hip OA. Longitudinal studies are therefore necessary to better characterise the risk factors and to establish preventive strategies in hip OA.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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ConclusionsKT plus quadriceps strengthening exercise does not offer advantages for improvement of pain compared with quadriceps strengthening exercise alone in knee OA.ResumenAntecedentesLos efectos benéficos del ejercicio en el tratamiento de la osteoartritis (OA) de rodilla han sido verificados en varios estudios. El vendaje kinesiológico o kinesiotaping (KT) se ha popularizado debido a la reducción de la presión local y el aumento de la circulación, lo que resulta en disminución del dolor.ObjetivoDeterminar la efectividad clínica de la terapia de fortalecimiento en conjun...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
The relationship between obesity and glenohumeral osteoarthritis is relatively understudied. The purpose of this study was to better define this relationship by age- and gender-matching 596,874 patients across six body mass index (BMI) cohorts and determining the prevalence of glenohumeral osteoarthritis and the standardized rate of glenohumeral arthroplasty in each cohort. Individuals with a BMI over 24 were found to be at increased odds for developing glenohumeral osteoarthritis, compared to the normal BMI cohort, and individuals with a BMI over 30 were additionally found to be at increased odds for undergoing glenohumeral arthroplasty.
Source: Orthopedic Clinics of North America - Category: Orthopaedics Authors: Source Type: research
Nature Reviews Rheumatology, Published online: 16 January 2020; doi:10.1038/s41584-020-0369-5Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
AbstractPurpose of ReviewDespite perceptions that osteoarthritis only affects older adults, many people develop osteoarthritis before 65  years of age and live decades with pain and disability. It is critical to understand why some adults develop osteoarthritis early in life and the consequences of aging with osteoarthritis.Recent FindingsOver half of people diagnosed with symptomatic knee osteoarthritis are under 65  years of age. Key risk factors are joint injury, certain occupations (e.g., tactical athletes), obesity, and aberrant hip shape. Young adults with osteoarthritis report significant mental health con...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
Adipokines have gained much interest in osteoarthritis (OA) pathogenesis studies over the past years in that they play crucial roles in bone and cartilage homeostasis. Obesity is known to be one of the well-recognized and modifiable causes of OA burden. Key mediators in this metabolic link between obesity and OA could be resistin, among other cytokines secreted by the adipose tissue. We aimed to evaluate the association of serum resistin with obesity, and inflammation in female patients with knee OA.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A rising level of TGF-β has long been associated with numerous aspects of aging. More modern research has shown it to encourage cells to become senescent. Further, TGF-β is an important component of the inflammatory mix of signals secreted by senescent cells, making it a part of the mechanism by which senescent cells can encourage their neighbors to also become senescent. When senescent cells fail to clear quickly, as happens in older individuals, this leads to a feedback loop of continually rising chronic inflammation and ever greater numbers of senescent cells. This is an important contribution to degenerative ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionsOur findings suggest the existence of homogeneous subgroups of participants and support the utility of identifying patterns of characteristics/risk factors that may cluster together and using them to identify subgroups of people who may be at a higher risk of developing and/or progressing OA.Key Points• Complex interplay among characteristics/factors leads to conflicting evidence between ambulatory activity and knee osteoarthritis.• Distinct subgroups are identifiable based on ambulatory activity, body mass index, knee pain, and comorbidities.• Identifying subgroups can be used to determine those ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionThis guideline provides direction for clinicians and patients making treatment decisions for the management of OA. Clinicians and patients should engage in shared decision ÔÇÉmaking that accounts for patients’ values, preferences, and comorbidities. These recommendations should not be used to limit or deny access to therapies.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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