Corticotropin-releasing hormone 1 receptor antagonism attenuates chronic unpredictable mild stress-induced depressive-like behaviors in rats

Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant activity, there is still little information on the potential interactions between corticotropin-releasing factor 1 receptor inhibitors and conventional antidepressant therapy. The aim of our study was to assess the influence of CP154526, a corticotropin-releasing factor 1 receptor blocker, which presented some signs of depression. Our results revealed that CP154526 (5 and 10 mg/kg) or fluoxetine (10 mg/kg) treatment notably improved the sucrose consumption, produced anti-depressive-like behavior in open-field test, as well as immobility time in forced swimming test. The levels of interleukin-6, interleukin-1β, tumor necrosis factor-α, and corticotropin-releasing hormone concentration in the serum were inhibited effectively by CP154526 or fluoxetine administration. Real-time quantitative PCR and western blot analysis showed the upregulated levels of brain-derived neurotrophic factor and growth associated protein 43 (GAP43) in the hypothalamus of the rats exposed to chronic unpredictable mild stress (CUMS), while different degrees of downregulation in their expression were detected after CP154526 (5 and 10 mg/kg) or fluoxetine (10 mg/kg) treatment, respect...
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research

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Abstract In recent years, the roles of astrocytes of the central nervous system in brain function and neurological disease have drawn increasing attention. As a member of the N-myc downstream-regulated gene (NDRG) family, NDRG2 is principally expressed in astrocytes of the central nervous system. NDRG2, which is involved in cell proliferation and differentiation, is commonly regarded as a tumor suppressor. In astrocytes, NDRG2 affects the regulation of apoptosis, astrogliosis, blood-brain barrier integrity, and glutamate clearance. Several preclinical studies have revealed that NDRG2 is implicated in the pathogene...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, spontaneous baroreflex sensitivity (SBRS) was also calculated through the sequence method by the computer software CardioSeries (v2.4). A baroreflex sequence was defined as a sequence of at least four heart beats in which both systolic arterial pressure and pulse interval increased (up sequences) or decreased (down sequences) as previously described (Braga et al., 2008). Evaluation of Sympathetic Tonus to the Vasculature In a separate group of rats, the sympathetic vascular tone was evaluated by an intravenous injection of hexamethonium (30 mg/Kg, Sigma-Aldrich, São Paulo, Brazil), a ganglionic bloc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Sara AlMarabeh, Mohammed H. Abdulla and Ken D. O'Halloran* Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland Renal sensory nerves are important in the regulation of body fluid and electrolyte homeostasis, and blood pressure. Activation of renal mechanoreceptor afferents triggers a negative feedback reno-renal reflex that leads to the inhibition of sympathetic nervous outflow. Conversely, activation of renal chemoreceptor afferents elicits reflex sympathoexcitation. Dysregulation of reno-renal reflexes by suppression of the inhibitory refle...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Uday Praful Kundap1,2, Yam Nath Paudel1, Yatinesh Kumari1, Iekshan Othman1 and Mohd. Farooq Shaikh1* 1Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia 2University of Montreal Hospital Centre (CRCHUM), Montreal, QC, Canada Epilepsy is a neuronal disorder associated with several neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Despite having more than 20 anti-epileptic drugs (AEDs), they only provide a symptomatic treatment. As well as, currently available AEDs also disp...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Nine years ago, Julie Kraft’s doctor uttered the words, “you have bipolar II disorder.” Immediately, images of unhinged film characters, sensationalist tabloid headlines and shocking news stories flooded her mind. All these things are now associated with me, she thought. Kraft felt embarrassed, ashamed, sad—and afraid. “I was fearful of being judged, backed away from, viewed as unsafe, unpredictable, unstable, an unreliable friend, an irresponsible mom, a moody wife, a woman of weak character, and the list goes on and on.” It’s an understandable reaction because even though bipolar...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders Stigma Bipolar Disorder bipolar disorder myths bipolar disorder stereotypes bipolar I Bipolar Ii Cyclothymia Hypomania Mental Health Stigma Mood Disorders Source Type: news
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractIn the recent 5  years (2014–2018), there has been growing interest in the use of machine learning (ML) techniques to explore image diagnosis and prognosis of therapeutic lesion changes within the area of neuroradiology. However, to date, the majority of research trend and current status have not been clearly il luminated in the neuroradiology field. More than 1000 papers have been published during the past 5 years on subject classification and prediction focused on multiple brain disorders. We provide a survey of 209 papers in this field with a focus on top ten active areas of research; i.e., Alzhe...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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