HIV treatment and prevention 2019: current standards of care

Purpose of review The purpose of this review is to summarize the current standards of care for both HIV treatment and HIV prevention in 2019. Recent findings Current HIV treatment is started as soon as feasible in a person with HIV infection and consists of a three-drug oral daily antiretroviral regimen, consisting of two nucleoside analogue reverse transcriptase inhibitors combined with a third drug, either an integrase inhibitor, a non-nucleoside reverse transcriptase inhibitor, or a protease inhibitor. Present treatment regimens are potent, convenient, generally well tolerated and durable, and lead to a normal life expectancy. Present antiretroviral-based HIV prevention strategies focus on treating people with HIV infection with antiretrovirals as soon as feasible to reduce their risk of transmitting to others, and providing two-drug pre-exposure prophylaxis (PrEP) and three-drug post-exposure prophylaxis (PEP) to those HIV-uninfected individuals who are at risk for HIV infection. PrEP is highly effective when used correctly. Further data on early antiretroviral therapy and PrEP are needed to demonstrate any impact on HIV epidemic control. Summary HIV treatment and HIV prevention have improved markedly in recent years due to the development of oral antiretrovirals that are potent, convenient, and generally well tolerated, and lead to virologic suppression and decreased HIV transmission.
Source: Current Opinion in HIV and AIDS - Category: Infectious Diseases Tags: LONG ACTING ART FOR TREATMENT AND PREVENTION: Edited by Martin Markowitz Source Type: research

Related Links:

ConclusionsThis is the first reported case of brucellosis concomitant with HIV infection in China. Laboratories in infectious disease hospitals and category A level III hospitals in the southern provinces of China should be equipped with reagents for clinical diagnosis of brucellosis and to strengthen the awareness of brucellosis diagnosis in China. Secondly, in provinces with a high incidence of AIDS and brucellosis such as Xinjiang and Henan, it is recommended to implement a joint examination strategy to ensure the early detection, diagnosis, and treatment of this infection.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 January 2020Source: The Lancet HIVAuthor(s): Oliver Ratmann, Joseph Kagaayi, Matthew Hall, Tanya Golubchick, Godfrey Kigozi, Xiaoyue Xi, Chris Wymant, Gertrude Nakigozi, Lucie Abeler-Dörner, David Bonsall, Astrid Gall, Anne Hoppe, Paul Kellam, Jeremiah Bazaale, Sarah Kalibbala, Oliver Laeyendecker, Justin Lessler, Fred Nalugoda, Larry W Chang, Tulio de OliveiraSummaryBackgroundInternational and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits of geo-targeted control, we assessed the ex...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
The list includes stopping infectious diseases and preparing for epidemics, expanding access to medicines, and protecting people from dangerous products.Medscape Medical News
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Internal Medicine News Source Type: news
AbstractPurpose of ReviewThe prevalence of Hepatitis C virus (HCV) in the US incarcerated population is disproportionately high, and when inmates with infection are released back into the general population, they play a substantial role in the spread of disease. This review provides support for targeting the jail/prison population to eliminate HCV in the general population. It will also summarize various screening/treatment models to curtail the burden of disease behind and beyond bars.Recent FindingsTransitioning from risk-based testing to opt-out testing in prisons/jails would be cost-effective through greater identifica...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
AbstractWe conducted a systematic review and meta-analysis to estimate the prevalence of adherence to antiretroviral therapy (ART) in India, the third largest HIV epidemic in the world. We identified peer reviewed literature published between 2007 and 2017 to extract data on ART adherence. We estimated pooled prevalence of adherence to ART using a random-effects model. Thirty-two eligible studies (n  = 11,543) were included in the meta-analysis. Studies were mostly clustered in the southern and western Indian states. Overall, 77% (95% Confidence Interval 73–82; I2 = 96.80%) of patients had...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
CONCLUSIONS: A high degree of population level HIV seroconcordance (both positive and negative) was observed at the time of forming new sexual partnerships. Understanding factors driving these patterns may help the development of strategies to bring the HIV epidemic under control. PMID: 31916420 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
[Nyasa Times] Malawi has beaten the United Nations Programme on HIV and Aids (UNAids) global HIV targets, a development that has given hope to the players that the country could be on the right path towards eradicating the epidemic by 2030.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Ronald S. Brookmeyer, professor of biostatistics and expert on how statistical tools can help address global public health challenges, will become the dean of the UCLA Fielding School of Public Health, effective Jan. 15.A member of the UCLA faculty since 2010, Brookmeyer has served as interim dean of the Fielding School since November 2018.“I am humbled by this opportunity to advance public health at our extraordinary public university,” Brookmeyer said. “With Fielding School faculty, staff and students, as well as colleagues and communities in our hometown of Los Angeles and far beyond, I look forward to...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Purpose of review To examine recent literature on the efficacy and effectiveness of HIV treatment in preventing HIV transmission through sexual exposure, at both an individual and at a population level. Recent findings Two recent studies on the individual-level efficacy of treatment as prevention (TasP) have added to the now conclusive evidence that HIV cannot be transmitted sexually when the virus is suppressed. However, four large cluster-randomized population-level trials on universal HIV testing and treatment in Africa have not delivered the expected impact in reducing HIV incidence at a population level. Two of t...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: HIV INFECTIONS AND AIDS: Edited by David Dockrell Source Type: research
Paul Cerrato and I have created a new book,Reinventing Clinical Decision Support, our first to be published about Platform thinking.  Although it is being published during my tenure at Mayo Clinic, it is not endorsed by Mayo Clinic and represents the personal opinions of Paul and me.  Below is the preface.In our last book, on mobile health(1),  we wrote about the power of words such as cynicism, optimism, and transformation. Another word with powerful connotations is misdiagnosis. To a patient whose condition remains undetected, it is a source of frustration and anger. To a physician or nurse who has be...
Source: Life as a Healthcare CIO - Category: Information Technology Source Type: blogs
More News: Epidemics | Epidemiology | HIV AIDS | Infectious Diseases | Virology