Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation

Bone Marrow Transplantation, Published online: 05 December 2019; doi:10.1038/s41409-019-0759-yMosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research

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CONCLUSION: Among all chemotherapeutic agents reviewed in our study which caused HSRs, asparaginase was the most co. PMID: 31981613 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Severe combined immunodeficiency (SCID) is a heterogeneous group of rare disorders caused by mutations in different genes involved in the development and function of immune cells. Patients with SCID are usually highly susceptible to severe opportunistic infection, and, if untreated, die within 1 year. Since the first successful bone marrow transplants in X-linked SCID and Wiskott-Aldrich syndrome, hematopoietic stem cell (HSC) transplantation (HSCT) has become the standard treatment for most patients with SCID.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
Many rare genetic disorders such as SCID (severe combined immunodeficiency) and osteopetrosis utilize bone marrow transplantation as a curative treatment. Each disorder individually is considered a rare entity, however below we describe a patient who not only was found to have both of these diseases, but his post natal course was also complicated by HLH and HHV 6 infection which created both a diagnostic and therapeutic challenge. No other patient with these constellation of disorders has been described in the literature.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.The study, published in Nature Communications,also sheds light on the basic biology behind blood stem cell regeneration and the role of a specific molecular process that is blocked by the new drug. Blood stem cells reside in the bone marrow and produce all of the body ’s blood and immune cells.“We’re very excite...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The first case of new-onset food allergy after transplantation was reported in 1997.1,2 Although posttransplantation food allergy (PTFA) is most common after liver transplantation, with a prevalence ranging from 5.6% to 38%, new-onset food allergy has also been described after bone marrow transplantation (BMT).2 –4 Tacrolimus, a medication used less frequently in BMT compared with solid organ transplantation, has been identified as a potentially modifiable risk factor for PTFA.2 Tacrolimus creates an immunologic imbalance that favors a TH2 response and increases intestinal permeability, which may increase allergen exposure via the gut.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
New-onset food allergy following transplantation is a described phenomenon, with the first case being reported in 1997.1,2 While post-transplantation food allergy (PTFA) is most common following liver transplantation with a prevalence ranging from 5.6 – 38%, new-onset food allergy has also been described following bone marrow transplantation (BMT).2-4 Tacrolimus, a medication used less frequently in BMT compared to solid organ transplantation, has been identified as a potentially modifiable risk factor for PTFA.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Abstract Genetically engineered T cells expressing chimeric antigen receptors (CAR) present a new treatment option for patients with cancer. Recent clinical trials of B cell leukemia have demonstrated a response rate of up to 90%. However, CAR cell therapy is frequently accompanied by severe side effects such as cytokine release syndrome and the development of target cell resistance. Consequently, further optimization of CARs to obtain greater long-term efficacy and increased safety is urgently needed. Here we high-light the various efforts of adjusting the intracellular signaling domains of CARs to these major re...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in progenito...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion In conclusion, this study wants to stress the importance of early diagnosis. As in the majority of primary immunodeficiency diseases, the prognosis of LAD3 is extremely dependent on early age diagnosis, with timely management of bacterial infections and consideration for HSCT. In addition, this autosomal recessive disorder has high incidence in areas with high rate of consanguineous marriages. Therefore, broadening the spectrum of known mutations underlying the phenotype of such a life-threatening disease can help offering and performing better genetic counseling and prenatal diagnosis. Ethics Statement This ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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