Translational Research Based on Understanding the Regulatory Mechanisms of in Vivo Behaviors of Fat-soluble Compounds.
[Translational Research Based on Understanding the Regulatory Mechanisms of in Vivo Behaviors of Fat-soluble Compounds]. Yakugaku Zasshi. 2019;139(12):1485-1494 Authors: Yamanashi Y Abstract Several fat-soluble compounds such as cholesterol and fat-soluble vitamins have important physiological activities in the body, and their excess and/or deficiency have been reported to be closely associated with the onset and progression of several conditions such as lifestyle-related diseases. It is important to clarify not only the physiological activities but also in vivo kinetics of fat-soluble compounds to understand their in vivo activity (toxicity). This review introduces our recent (reverse) translational research in a combination of basic and clinical studies to reveal the regulatory mechanisms of in vivo behaviors of fat-soluble compounds and effects of their disruption in humans. PMID: 31787634 [PubMed - in process]
In conclusion, the findings of the present study indicated that DHA may significantly decrease the serum TG levels and alter the gut microbiota, which suggested its potential to be used for the treatment of hyperlipidemia, inflammatory and neurodegenerative disorders. PMID: 32468008 [PubMed - as supplied by publisher]
Authors: Kalli E Abstract Lipids constitute almost 60% of the brain's dry weight, and they are thought to be involved in inflammation, neurotransmission and synaptic plasticity. The brain mostly contains sphingolipids, glycerophospholipids and cholesterol which are abundant in myelin and neuronal membranes. The recent rise of the promising area of lipidomic data can be used as a diagnosing tool at the early stages of Alzheimer's disease allowing novel therapeutic targets. In this review, altered lipid metabolites as well as the impact of diet in the progress of Alzheimer's disease (AD) are analyzed. PMID: 32468...
AbstractEffects of statins over clinical changes in Alzheimer ’s disease (AD) are usually non-significant, but epistatic interactions between genetic variants involved in cholesterol metabolism could be important for such effects. We aimed to investigate whetherLDLR single-nucleotide polymorphisms rs11669576 (LDLR8), rs5930 (LDLR10), and rs5925 (LDLR13) are associated with cognitive and functional changes in AD, while also consideringAPOE haplotypes and lipid-lowering treatment with lipophilic statins for stratification. Consecutive outpatients with late-onset AD were screened with cognitive tests, while caregivers s...
Familial hypercholesterolaemia is often symptomless, but if untreated, patients can die before reaching middle age or even as children, like Rianna Wingett from Essex, pictured.
HOW to live longer: Prevent an early death by eating a healthy, balanced diet, and by doing regular exercise. But you could also increase your life expectancy, while also lowering your chances of high cholesterol, by eating spicy foods everyday.
Conclusions: The present study provides valuable knowledge on the potential benefits of statins in kidney transplant recipients. This meta-analysis shows that statin therapy modifies the lipid profile in this patient population. PMID: 32462035 [PubMed - in process]
CONCLUSION: In hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. In this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction. PMID: 32462219 [PubMed - as supplied by publisher]
Publication date: July 2020Source: American Heart Journal, Volume 225Author(s): Harvey D. White, Ralph A.H. Stewart, Anthony J. Dalby, Amanda Stebbins, Christopher P. Cannon, Andrzej Budaj, Ales Linhart, Prem Pais, Rafael Diaz, Philippe Gabriel Steg, Sue Krug-Gourley, Christopher B. Granger, Judith S. Hochman, Wolfgang Koenig, Robert A. Harrington, Claes Held, Lars Wallentin, on behalf of the STABILITY Investigators
AbstractChanges in neurovascular coupling are associated with both Alzheimer ’s disease and vascular dementia in later life, but this may be confounded by cerebrovascular risk. We hypothesized that hemodynamic latency would be associated with reduced cognitive functioning across the lifespan, holding constant demographic and cerebrovascular risk. In 387 adults aged 18–85 (mean = 48.82), dynamic causal modeling was used to estimate the hemodynamic response function in the left and right V1 and V3-ventral regions of the visual cortex in response to a simple checkerboard block design stimulus with mi...
Conditions: COVID; Statin; Cardiovascular Diseases Intervention: Drug: observational Sponsor: Institut Investigacio Sanitaria Pere Virgili Recruiting