The interplay of sun-damage and genetic risk in Australian multiple and single primary melanoma cases and controls.

CONCLUSION: Our cohort demonstrated higher frequencies of previously reported alleles associated with melanoma. MPM melanomas more commonly occur in UV-damaged areas, and these individual are more likely to carry MC1R RHC alleles. Awareness of the interplay of genetic vulnerability with UV damage can stratify risk and guide recommendations for melanoma screening.
PMID: 31794051 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - December 2, 2019 Category: Dermatology Authors: McMeniman EK, Duffy DL, Jagirdar K, Lee KJ, Peach E, McInerney-Leo AM, De'Ambrosis B, Rayner JE, Smithers BM, Soyer HP, Sturm RA Tags: Br J Dermatol Source Type: research