What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? - A systematic review.

CONCLUSIONS AND RELEVANCE: Evidence on FLG-environment interactions in atopic dermatitis aetiology is limited. However, many of the studies lacked large enough sample sizes to fully assess these interactions. Further research is needed with larger sample sizes and clearly defined exposure assessment. PMID: 31794059 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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This study is a case–referent study including patients registered in the National Database of Contact Allergy, Denmark, and comprises data on sex, a ge, atopic dermatitis, HE, face eczema and patch testing results. Patients with HE served as cases and patients with facial eczema served as referents. Information on profession was retrieved from the DOC*X database in accordance with the DISCO-88 classification system. A wet-work-specific JEM provi des – for each profession – an estimate for (i) the likelihood of wet work lasting ≥2 hours/day and (ii) the average number of hours of wet work per day. Resu...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Original article Source Type: research
Pruritus and inflammation are the most common symptoms in skin diseases, including eczema, atopic dermatitis and allergic contact dermatitis [1]. The warm temperature-sensitive and calcium-permeable transient receptor potential vanilloid 3 (TRPV3) channel is abundantly expressed in the keratinocytes, and gain-of-function mutations of TRPV3 cause skin pruritus and inflammation in rodents and humans, suggesting that pharmacological inhibition of overactive TRPV3 may be beneficial for therapy of pruritus or dermatitis [2].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
Atopic dermatitis severity measures for clinical research are time-consuming, but simple measures (Global Assessment; Body Surface Area) are incomplete and complementary. The product of Investigator Global Assessment and body surface area provides a rapid office-based severity measurement of pediatric atopic dermatitis that compares well with more cumbersome assessments.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
This study is a case-referent study including patients registered in the National Database of Contact Allergy, Denmark, and comprises data on sex, age, atopic dermatitis, HE, face eczema and patch testing results. Patients with HE served as cases and patients with facial eczema served as referents. Information on profession was retrieved from the DOC*X database in accordance with the DISCO-88 classification system. A wet-work-specific JEM provides - for each profession - an estimate for (i) the likelihood of wet work lasting ≥2 hours/day and (ii) the average number of hours of wet work per day. Results After two hours o...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Authors: Tags: Scand J Work Environ Health Source Type: research
We present the results of our study on the microbiota of apparently healthy skin in children with atopic eczema (AE) exacerbation and skin microbiota in remission. The study revealed that the skin microbiota in children with AE signi ficantly differs from that of healthy controls. The differences include not the quantitative but also qualitative skin microbiota composition both on AE lesions and apparently healthy skin, where the bacterial number exceeds that on the skin of the control group children by 2-4 times. We also observ ed qualitative bacterial imbalance and appearance and prevalence of microorganisms not typical ...
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research
ConclusionsThe prevalence of p-phenylenediamine allergy remains high among patients with contact eczema. Risk factors for p-phenylenediamine contact allergy are consistent with previous reports.ResumenAntecedentes y objetivosEl objetivo del trabajo es mostrar la tendencia de la sensibilización de contacto entre los años 2004-2014 tras la regulación de su concentración en cosméticos en el año 2009 e investigar los factores de riesgo de la alergia de contacto a la parafenilendiamina.Material y métodosEl diseño del estudio fue observacional retrospectivo incluyendo pacie...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Discussion: The results of our pilot study confirm the efficacy and tolerability of this new topical formulation in a real-life assessment and patients showed strong adherence to therapy. These promising results - still to be confirmed on a larger number of patients - emphasize the potential SEB has in controlling the chronic inflammation of seborrheic dermatitis. PMID: 31920359 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Conclusion: Eczema is the most prevalent skin infection among the elderly population. Age, consumption of alcohol, usage of more than five medicines simultaneously and presence of co-morbidities are the main factors that are involved in better treatment outcomes of skin infections among study population. PMID: 31916477 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
ConclusionsIn the future and prior to initiating clinical trials, the safety, in vitro and in vivo pharmacology, and mechanism of action of MP needs to be assessed, including a focus on the link between traditional uses and modern applications. In addition, phytochemical and biological studies need to conduct on flowers and fruits of MP. Furthermore, strict quality control measures are needed in the studies investigating any aspect of the pharmacology, chemistry and biology of MP.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Title: Atopic Dermatitis vs. EczemaCategory: Diseases and ConditionsCreated: 1/2/2020 12:00:00 AMLast Editorial Review: 1/2/2020 12:00:00 AM
Source: MedicineNet Skin General - Category: Dermatology Source Type: news
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