Clinical assessment of tolerability, immunological and cutaneous reactivity effects of an abbreviated schedule with Olea europaeanative extract of subcutaneous immunotherapy.

Conclusions. Olea europaea SCIT (Allergovac® depot ROXALL Medicina España S.A.) showed a good safety and tolerability profile. Immunological changes with induction of blocking IgG and decreases in cutaneous reactivity were detected in the patients. PMID: 31789492 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

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Conclusions. Although there was no increase in Api m10 sIgG4 levels after 1 year bVIT, we did not observe relevant differences in other outcomes between patients with predominant Api m1 or Api m10 sensitization. PMID: 31939631 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
ConclusionsPooled data indicate that short- and long-term timothy grass SLIT-tablet is well tolerated in children, regardless of geographic region. AEs were generally local, mild, and transient allergic reactions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsEPIT using HG is a safe method to enable oral administration even in patients with severe milk allergies.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewThe prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of durability of desensitization. Additionally, it is allergen-specific, and in those allergic to multiple allergens, the length and cost of treatment are further increased. In this review, we summarize recent developments in novel non-allergen-specific treatments for food allergy.Recent FindingsA number of m...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Authors: Kim EH, Patel C, Burks AW Abstract Introduction: Peanut allergy has continued to increase in prevalence and despite efforts to prevent the allergy with early peanut introduction, treatments for those already with the allergy have been lacking. While the physical effects of peanut allergy have been well known, what has more recently begun to be discussed are the broad psychosocial and financial implications that are also related to the allergy. Oral (OIT), epicutaneous (EPIT), and sublingual (SLIT) immunotherapy have been developed as potential treatments for peanut allergy.Areas covered: Pivotal clinical t...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Cow's milk (CM) is a common allergen present in immunoglobulin E (IgE)-mediated food allergy in children. The management of CM allergy (CMA) requires the replacement of milk protein with alternative protein and calcium sources. Extensively hydrolyzed formulas (eHFs) are alternative, hypoallergenic formulas that are recommended as standards for children with CMA.1 IgE-mediated immediate reactions to eHFs, such as life-threatening anaphylaxis, rarely occur.2 Patients with hyperresponsiveness to eHFs may be at a high risk because they are on a complete elimination diet.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Letter to the Editor Source Type: research
Publication date: Available online 9 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer A. Dantzer, Kim Mudd, Robert A. Wood
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Condition:   Peanut Allergy Intervention:   Drug: Peanut oral immunotherapy Sponsor:   Massachusetts General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewThis review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease.Recent FindingsCircadian rhythms driven by cell-autonomous biological clocks are central to innate and adaptive immune responses against microbial pathogens. Research during the past few years has uncovered circadian circuits governing leukocyte migration between tissues, the magnitude of mucosal inflammation, the types of cytokines produced, and the severity of im...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Condition:   Peanut Allergy Intervention:   Drug: Peanut oral immunotherapy Sponsor:   Massachusetts General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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