Regulation of Barrier Immunity and Homoeostasis by Integrin-Mediated TGF β activation.

Regulation of Barrier Immunity and Homoeostasis by Integrin-Mediated TGFβ activation. Immunology. 2019 Dec 02;: Authors: McEntee CP, Gunaltay S, Travis MA Abstract Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. Various cell types secrete TGFβ, but always as an inactive complex. Thus, for TGFβ to function, this latent complex must somehow be activated. Work in recent years has highlighted a critical role for members of the αv integrin family, including αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8 that are involved in TGFβ activation in various contexts, particularly at barrier sites such as the gut, lung and skin. The integrins facilitating this context- and location-specific regulation can be dysregulated in certain diseases, and thus are potential therapeutic targets in a number of disorders. In this review, we discuss the role of TGFβ at these barrier sites with a focus on how integrin-mediated TGFβ activation regulates tissue and immune homoeostasis, and how this is altered in disease. PMID: 31792952 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research