EGFR inhibition for metastasized cutaneous squamous cell carcinoma in dystrophic epidermolysis bullosa

Dystrophic epidermolysis bullosa (DEB) is a hereditary skin fragility disorder, characterized by trauma-induced blistering followed by soft tissue fibrosis. One of the most feared complications is the early de...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Letter to the Editor Source Type: research

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Publication date: Available online 28 January 2020Source: Urology Case ReportsAuthor(s): Shinro Hata, Satoki AbeAbstractIn the Checkmate-025 trial, nivolumab treatment prolonged overall survival among patients with previously treated advanced renal cell carcinoma (RCC) compared with treatment with everolimus. Although effective, nivolumab is associated with immune-related adverse events (irAEs). However, the occurrence of hematological irAEs is rare. Some studies have reported on nivolumab-induced thrombocytopenia. Nivolumab associated thrombocytopenia in almost all patients improved with administration of various drugs. H...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionRadiologists were able to predict invasive disease better than chance, particularly for smaller DCIS lesions (
Source: Academic Radiology - Category: Radiology Source Type: research
This study aimed to investigate the effects of ferulic acid on HeLa and Caski human cervical carcinoma cells and the molecular mechanisms involved. MATERIAL AND METHODS HeLa and Caski human cervical carcinoma cells were grown in culture and treated with increasing doses of ferulic acid. The MTT assay was used to evaluate cell viability. Flow cytometry was performed with 4',6-diamidino-2-phenylindole (DAPI) and Annexin V staining for cell apoptosis. The expression of myeloid leukemia cell differentiation-1 (Mcl-1) protein and MCL-1 mRNA were determined by Western blot and reverse transcription-polymerase chain reaction (RT-...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Condition:   EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC Interventions:   Drug: Atezolizumab;   Drug: Bevacizumab;   Drug: Carboplatin;   Drug: Paclitaxel;   Drug: Pemetrexed Sponsors:   European Thoracic Oncology Platform;   Roche Pharma AG Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Colorectal Cancer;   Ovarian Cancer;   Non Small Cell Lung Cancer;   Acral Lentiginous Melanoma Intervention:   Biological: ATRC-101 Sponsor:   Atreca, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Renal Cell Carcinoma Intervention:   Device: contrast CT Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Surgical Procedure;   Disease Free Survival;   Overall Survival Intervention:   Sponsor:   Universidad de Extremadura Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, the PD-L1+ Breg cells were investigated. The expression of PD-L1 by circulating B cells was very low in healthy controls. In melanoma patients, on the other hand, the expression of PD-L1 by circulating B cells was significantly elevated in a manner that was positively associated with tumor stage, with the highest level in stage IV bone metastasis patients. Compared to total B cells, PD-L1+ B cells presented higher IgM and higher IgD expression, and were almost exclusively CD20+CD27−, suggesting that the PD-L1+ B cells exhibited a naive B cell-like phenotype. Healthy naive B cells, which presented littl...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThe cytopathologic features of Xp1RCC are relatively non-specific, and overlap with other renal cell carcinoma subtypes. A definitive diagnosis is only possible with ancillary immunohistochemistry with or without additional TFE3 FISH.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Inherited epidermolysis bullosa (EB) comprises a highly heterogeneous group of rare diseases characterized by exacerbated skin and/or mucosal fragility and blister formation after minor mechanical trauma. Leve...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Source Type: research
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