Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease

Condition:   Parkinson Disease Intervention:   Device: Deep Brain Stimulation Sponsors:   Northwell Health;   National Institute of Neurological Disorders and Stroke (NINDS);   The University of Tennessee, Knoxville Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Abstract Deep brain stimulation (DBS) of single-target nuclei has produced remarkable functional outcomes in a number of movement disorders such as Parkinson's disease, essential tremor, and dystonia. While these benefits are well established, DBS efficacy and strategy for unusual, unclassified movement disorder syndromes is less clear. A strategy of dual pallidal and thalamic electrode placement is a rational approach in such cases where there is profound, medically refractory functional impairment. The authors report a series of such cases: midbrain cavernoma hemorrhage with olivary hypertrophy, spinocerebellar ...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Condition:   Parkinson Disease Intervention:   Device: Deep Brain Stimulation Sponsors:   Northwell Health;   National Institute of Neurological Disorders and Stroke (NINDS);   The University of Tennessee, Knoxville Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Dystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen after stroke, injury, or as a result of genetic causes. LID is associated with Parkinson's disease (PD), emerging as a consequence of chronic therapy with levodopa, and may be either dystonic or choreiform. LID and dystonia share important phenomenological properties and mechanisms. Both LID and dystonia are generated by an integrated circuit involving the cortex, basal ganglia, thalamus and cerebellum. They also share dysregulation of striatal choliner...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Abbott Laboratories and the National Institutes of Health have formed an alliance to evaluate applications that could help treat chronic pain and progressive movement disorders, like Parkinson’s disease. The collaboration is a part of NIH’s BRAIN (Brain Research through Advancing Innovative Neurotechnologies) initiative to accelerate advancements in neuroscience research. The agreement specifically calls for NIH to use the Abbott Park, IL-based company’s neuromodulation technologies for research related to these NIH initiatives to explore their application for chronic p...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
In this study, we focused primarily on the change of sensory weighting parameters when sensory conditions change. We also tested the additional hypothesis that levodopa medication would improve sensory weighting for postural control. Materials and Methods Subjects The Institutional Review Board at Oregon Health and Science University (OHSU) approved the protocol for this experiment, and all subjects gave informed consent prior to participating. Eight subjects with PD (three female) and eight healthy, age-matched controls (two female) were recruited from the Balance Disorders Laboratory database and the Parkinson’s...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
This study underscores the importance of chronic stimulation in the modulation of sensorimotor integration and proprioception. The authors considered two possible mechanisms underlying SAI modulation by STN DBS. High-frequency DBS of the STN might normalize synchronization between basal ganglia structures, which might restore the ability of thalamocortical relay cells to respond to depolarizing inputs involved in sensorimotor integration (Brown et al., 2001; Rubin and Terman, 2004). Alternatively, STN DBS might have a direct effect on cortical structures through antidromic stimulation of the cortico-subthalamic pathway. I...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Abstract Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson's disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the po...
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
Conclusion: The rates of both early and late complications of DBS surgery are acceptably low and decrease significantly with cumulative experience. PMID: 30140425 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
adapted from Figure 3 (Koroshetz et al., 2018). Magnetic resonance angiography highlighting the vasculature in the human brain in high resolution, without the use of any contrast agent, on a 7T MRI scanner. Courtesy of Plimeni&Wald (MGH).[ed. note: here's a great summary onIf, how, and when fMRI goes clinical, by Dr. Peter Bandettini.]TheJournal of Neuroscience recently published a paywalled article onThe State of the NIH BRAIN Initiative.This paper reviewed the research and technology development funded by the “moonshot between our ears” [anewly coined phrase]. The program has yielded a raft ofpublications...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
Deep brain stimulation (DBS) for Parkinson’s disease management has been shown to be quite effective in controlling the symptoms of the disease. Yet, the technology currently available to patients is rudimentary in that the neurostimulatio...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Neurosurgery Rehab Source Type: blogs
More News: Brain | Deep Brain Stimulation | Neurology | Parkinson's Disease | Research | Stroke