Immunogenicity and Safety of Rotavirus RV3 Vaccine (Bio Farma) in Neonates
Condition: Rotavirus Gastroenteritis Interventions: Biological: Rotavirus RV3 Vaccine (Bio Farma); Other: Placebo Sponsor: PT Bio Farma Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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From 2016, the Government of India introduced the oral rotavirus vaccine into the national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Instit...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Sidhartha Giri, C. P. Girish Kumar, Shainey Alokit Khakha, Mamta Chawla-Sarkar, Varanasi Gopalkrishna, Shobha D. Chitambar, Pratima Ray, S. Venkatasubramanian, Biswa Jyoti Borkakoty, Subarna Roy, Jyothi Bhat, Bhagirathi Dwibedi, Pradeep Das, Vijayachari P Tags: Research article Source Type: research
We present a case of a 27-month-old girl who was hospitalized for 4 days with severe gastroenteritis, including high fever, vomiting, diarrhea, mild dehydration, and periumbilical pain. Notably, the patient previously received the Rotarix vaccine.
Diagnoses:
The laboratory tests were negative for rotavirus, astrovirus, adenovirus, and norovirus as well as common diarrhea-causing bacteria. Human-bovine recombinant rotavirus was detected by MinION sequencing.
Interventions:
To investigate the cause agents from the unexplained severe gastroenteritis infant, the stool sample was prepared by random amplification for Nanop...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ro JJ
Abstract
PURPOSE: Although quantitative benefit-risk models (qBRms) are indisputably valuable tools for gaining comprehensive assessments of health care interventions, they are not systematically used, probably because they lack an integrated framework that provides methodologic structure and harmonization. An alternative that allows all stakeholders to design operational models starting from a standardized framework was recently developed: the discretely integrated condition event (DICE) simulation. The aim of the present work was to assess the feasibility of implementing a qBRm in DICE, using the example o...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Arlegui H, Nachbaur G, Praet N, Bégaud B, Caro JJ Tags: Clin Ther Source Type: research
Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a d...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: M ónica López-Lacort, Alejandro Orrico-Sánchez, Miguel Ángel Martínez-Beneito, Cintia Muñoz-Quiles and Javier Díez-Domingo Tags: Research article Source Type: research
Globally, group A rotaviruses (RV-A) are the primary causative agents of acute gastroenteritis requiring hospitalization among infants and young children
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Joshua Ndung ’u Gikonyo, Betty Mbatia, Patrick W. Okanya, George F.O. Obiero, Carlene Sang, Duncan Steele, James Nyangao Source Type: research
Cost of pediatric hospitalizations in Burkina Faso: A cross-sectional study of children aged
Source: Vaccine - Category: Allergy & Immunology Authors: Aliabadi N, Bonkoungou IJO, Pindyck T, Nikièma M, Leshem E, Seini E, Kam M, Konaté S, Ouattara M, Ouédraogo B, Gue E, Nezien D, Ouedraogo I, Parashar U, Medah I, Mwenda JM, Tate JE Tags: Vaccine Source Type: research
The purpose of this double-blind, randomised, placebo-controlled, adaptive design trial with frequent interim analyses is to determine if Australian Indigenous children, who receive an additional (third) dose ...
Source: Trials - Category: General Medicine Authors: Mark A Jones, Todd Graves, Bianca Middleton, James Totterdell, Thomas L Snelling and Julie A Marsh Tags: Update Source Type: research
We examined different coverage levels and assumptions regarding the waning effects and intussusception case fatality rate.ResultsWith the current vaccination coverage of
Source: Eurosurveillance - Category: Infectious Diseases Authors: Sylvie Escolano, Judith E Mueller and Pascale Tubert-Bitter Source Type: research
Authors: Fathima P, Jones MA, Moore HC, Blyth CC, Gibbs RA, Snelling TL
Abstract
BackgroundRotavirus vaccination was introduced into the Australian National Immunisation Program in mid-2007. We aimed to assess the impact of the rotavirus vaccination program on the burden of hospitalisations associated with all-cause acute gastroenteritis (including rotavirus gastroenteritis and non-rotavirus gastroenteritis) in the Aboriginal and non-Aboriginal population in Western Australia.MethodsWe identified all hospital records, between July 2004 and June 2012, with a discharge diagnosis code for all-cause gastroenteritis. Ag...
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Conclusion: This study shows that Rotavirus can be shed into environments without any signs and symptoms. In view of this, the Rotavirus vaccine should be considered a priority and be introduced in the existing national immunization program in Nigeria, particularly in Borno State.
Source: Annals of African Medicine - Category: African Health Authors: Monilade T Akinola Auwalu Uba Ahmed F Umar Ediga B Agbo Source Type: research
