Left Ventricular Dysfunction and Persistent Perfusion Abnormalities in Infants with Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) is a complex disease that causes severe hypoxemic respiratory failure and significant morbidity and mortality.1 In the most severe cases, CDH is characterized by lung hypoplasia, severe pulmonary hypertension (PH), and cardiac dysfunction.2 Despite many advances in therapeutic options for CDH, the related PH and poor cardiac function often remain refractory to medical interventions, such as inhaled nitric oxide (iNO) therapy, and persist as the most common indications for extracorporeal membrane oxygenation therapy (ECMO) in the newborn period.

Source: The Journal of Pediatrics - December 3, 2019 Category: Pediatrics Authors: Erica W. Mandell, John P. Kinsella Tags: Editorials Source Type: research