Insular Risk Processing Predicts Alcohol Use Via Externalizing Pathway in Male Adolescents.

CONCLUSIONS: The findings suggest gender differences in vulnerability to later alcohol use, specifically in terms of how a neurobiological susceptibility to risk insensitivity may disproportionately influence male adolescents' externalizing symptomatology. Male adolescents who do not effectively integrate risk-related signals are likely to engage in externalizing behaviors, which in turn are related to later alcohol use. Findings also suggest differential roles of risk-related brain function that contribute to gendered pathways to adolescent health-risk behaviors. PMID: 31790350 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research

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The objective of the technique is to establish a possible neural marker that could identify which teenagers would abuse alcohol when they entered adulthood and devise interventions that might delay alcohol use. The researchers used BOLD MRI on 29 participants who drank minimal alcohol between the ages of 12 and 14, and over the course of the study, 15 had evolved into binge drinkers. The BOLD inhibitory control test was used to determine blood flow changes that happened in tandem with neuron activation. In the group ’s initial imaging round at age 18, participants were asked to press a button when they saw ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
acute;, França M Abstract AIM: To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease. MATERIAL AND METHODS: This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequenc...
Source: Radiologia - Category: Radiology Authors: Tags: Radiologia Source Type: research
Obstructive sleep apnoea (OSA) and non-alcoholic fatty liver disease (NAFLD) are two of many diseases associated with obesity. NAFLD is a common condition ranging in severity from liver steatosis to non-alcoholic steatohepatitis and liver fibrosis, the last step of NAFLD progression. Numerous studies have investigated whether the frequent co-occurrence of OSA and NAFLD simply reflects their link to obesity, or whether there is an independent pathophysiological interconnection between the two diseases (see [1] for comprehensive review). In animal models, intermittent hypoxia mimicking OSA has been shown to cause insulin res...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Conditions:   NAFLD;   Heart Failure;   Valvular Disease;   Coronary Disease Intervention:   Diagnostic Test: T1 mapping on Cardiovascular Magnetic Resonance Studies Sponsor:   Dr. Andreas Kammerlander Not yet recruiting
Source: - Category: Research Source Type: clinical trials
We present a case of Broca aphasia that was initially interpreted as confusion. CASE PRESENTATION: A 76-year-old woman was brought to the Emergency Department because of confusion and slurred speech that began in the morning. The patient had an extensive history of alcohol abuse, hyperlipidemia, and hypertension and had recently quit drinking 5 days earlier. The patient appeared confused, answering questions with "I don't know," but had no signs of agitation. Magnetic resonance imaging of the brain confirmed a recent infarct involving the left frontal and occipital lobes, coinciding with the Broca area. The p...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
CONCLUSIONS: These findings show for the first time that implementation intentions targeting cognitive processes can significantly reduce alcohol consumption among heavy drinkers. However, there was no evidence that the effects were mediated by changes in neural activity. Further work is required to explore the neural mechanisms underpinning the operation of implementation intentions. TRIAL REGISTRATION: This trial was registered (ISRCTN:35503634) and is available at PMID: 31819947 [PubMed - as supplied by publisher]
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Tags: Ann Behav Med Source Type: research
ConclusionThe patient started treatment using B12 vitamin, thiamine, and physical therapy. Currently, despite reported balance improvement, he needs ambulation support. He features nystagmus, bilateral dysmetria, mild dysdiadochokinesia, continuous tinnitus in his left ear, blurred vision, and neck pain while moving it.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
CONCLUSIONS: These findings suggest that delayed structural maturation of the NAcc may be a risk factor for alcohol use in adolescence; however, the mechanism by which the structure of the NAcc confers risk differs by sex. PMID: 31790349 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
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