Genetic characterization of variants of HPV ‑16, HPV‑18 and HPV‑52 circulating in Italy among general and high‑risk populations.

Genetic characterization of variants of HPV‑16, HPV‑18 and HPV‑52 circulating in Italy among general and high‑risk populations. Mol Med Rep. 2019 Nov 25;: Authors: Frati ER, Bianchi S, Amendola A, Colzani D, Petrelli F, Zehender G, Tanzi E Abstract Viral factors, such as high‑risk human papillomavirus variants, can increase the risk of viral persistence and influence the progression to cancer. In the present study, the long control region (LCR) of human papillomavirus (HPV)‑16 and HPV‑52, and the L1 region of HPV‑16 and HPV‑18, identified from subjects belonging to both general and high‑risk populations (migrants, HIV+ subjects and adolescent/young people) residing in Italy, were characterized using molecular and phylogenetic techniques. To the best of our knowledge, this is the first Italian study to analyze a large number of sequences (n=458) and report phylogenetic data on the HPV‑52 variants. The phylogenetic analysis showed that 90% of the LCR variants of HPV‑16 and HPV‑52 clustered within lineage A (European lineage) and only sequences identified from subjects belonging to high‑risk populations fell into the non‑European lineages. Analysis of the LCRs revealed a high genomic diversity with a large number of changes. Several mutations in the binding sites for viral and cellular transcription factors characterized the HPV‑16 LCR variants belonging to the African lineages B and C, were observed in subjects with cytologic...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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Identifying risk factors for human papillomavirus (HPV) infection in the post-vaccination era among men is necessary for the design of evidence-based interventions to prevent HPV-related cancers. No previous studies have examined both individual- and partner-level (sexual networking) factors associated with HPV in men after vaccine introduction. The study aim was to determine individual- and partner-level factors associated with HPV infection (>1 HPV type and HPV16/18) in vaccinated and unvaccinated men.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
This study concludes that adolescents are poorly informed about the HPV and the preventive vaccination issues, underestimating the likelihood of the infection by the virus. The way to improve their knowledge about the HPV and the implications of the HPV infection is to provide information through the framework of compulsory schooling, primary health care, and th e development of informative interactive interventions. The awareness for the need of training about the HPV and its implications should be broadened to address the major barrier to vaccination, which is regarded to be the lack of adequate information. The knowledg...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: The authors found relatively higher and increasing incidence rate of OPC in Florida and lower rate of HPV vaccination among adolescents in Florida than in the nation overall. PRACTICAL IMPLICATIONS: The trends illustrated may stimulate policy changes to increase HPV vaccination for children and enhance the understanding of its benefits. PMID: 31902400 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
AbstractIn 2017, HPV vaccines were first marketed in China. We carried out an investigation among parents of high school students to assess parents ’ knowledge of cervical cancer and human papillomavirus (HPV)/HPV vaccines, along with their acceptance of HPV vaccination and the factors that influence it, all of which are essential for targeted education regarding HPV vaccination. A cross-sectional study was conducted among parents of high sch ool students in East China using a pretested questionnaire. Data regarding knowledge of cervical cancer, HPV, HPV vaccines, and acceptance of the vaccines were collected and ana...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
First introduced in 2006, the multi-dose human papillomavirus (HPV) vaccine can prevent most cervical and anal cancers among children and young adults exposed to the virus. It can also prevent the majority of both HPV-driven oral and penile cancers.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Abstract Studies with prophylactic HPV vaccination have demonstrated impressive efficacy, immunogenicity, and safety results; however, the implementation and uptake in both low and high-income countries continues to be challenging. Since 2006, administration guidelines have undergone multiple updates regarding age, dosing schedule, and gender. Despite these changes, the basic tenet remains the same: prioritize immunization before initiation of sexual activity and subsequent exposure to HPV. The importance of immunizing males and females equally and the role for catch-up vaccination in late adolescent and adulthood...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
New evidence published in the Cochrane Library today provides further information on the benefits and harms of different human papillomavirus (HPV) vaccines and vaccine schedules in young women and men.HPV is the most common viral infection of the reproductive tract in both women and men globally (WHO 2017). Most people who have sexual contact will be exposed to HPV at some point in their life. In most people, their own immune system will clear the HPV infection.HPV infection can sometimes persist if the immune system does not clear the virus. Persistent infection with some ‘high-risk’ strains of HPV can lead t...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
This is a public health success story. A landmark report on the effectiveness of the quadrivalent human papillomavirus vaccine (4vHP) in the U.S. is now a matter of medical record. Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the U.S., with nearly 80 million people infected with some type of HPV at some point in their lives [1]. About 14 million Americans, including teens, become infected each year [2]. HPV causes genital warts and is associated with an estimated 33,700 newly diagnosed cancers every year in the U.S.
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Editorial Source Type: research
This study firstly determined the knowledge of risk factors and prevention of cervical cancer. Secondly, it checked an association between mothers’ screening practice and student’s knowledge. A descriptive, cross sectional study was conducted among 253 pairs of high school students and their mothers. Knowledge on cervical cancer was significantly lower among students and mothers. While cancer screening tests, maintenance of hygiene were considered as major preventive measures for cervical cancer, human papilloma vaccine was the least considered preventive measure. Students who were female, attended disc...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Did you know that a viral infection can lead to a number of different types of cancer? If that comes as a surprise to you, you’re not alone. In fact, according to a new study, many people have no idea that a common viral infection called human papilloma virus (HPV) can cause cancer of the genitals, anus, mouth, and throat, as well as cervical cancer. Viral infections and cancer The connection between certain viral infections and cancer has been recognized for many years. Some of the most well-established examples include hepatitis C, human immunodeficiency virus (HIV), and human papillomavirus (HPV). One thing these ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Cancer Infectious diseases Men's Health Sexual Conditions Vaccines Women's Health Source Type: blogs
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