Placenta specific protein-1 in recurrent pregnancy loss and in In Vitro Fertilisation failure: a prospective observational case-control study.

This study has demonstrated higher PLAC1 levels in infertile women with RIF and RPL for the first time; suggesting that it could have a negative effect on implantation in these populations. PLAC1 could be detected in the serum as a biomarker that is associated with RIF and RPL. What are the implications of these findings for clinical practice and/or further research? Defining the precise role of PLAC1 during implantation will provide new insight into understanding of poor reproductive outcomes such as RIF and RPL and help in developing treatment strategies. Further large-scale studies with more patients are needed to uncover the clinical value of PLAC1 as a biomarker to predict repeated implantation failure and RPL. PMID: 31791163 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

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Authors: PMID: 31977405 [PubMed - in process]
Source: The American Journal of Nursing - Category: Nursing Tags: Am J Nurs Source Type: research
Authors: PMID: 31977403 [PubMed - in process]
Source: The American Journal of Nursing - Category: Nursing Tags: Am J Nurs Source Type: research
Publication date: Available online 24 January 2020Source: The American Journal of SurgeryAuthor(s): Jason M. Bowie, Richard Y. Calvo, Vishal Bansal, Lyndsey E. Wessels, William J. Butler, C. Beth Sise, Jennifer G. Shaw, Michael J. SiseAbstractBackgroundComplicated gallstone disease (CGD) is a common condition requiring intervention during pregnancy to avert adverse birth outcomes (ABO).MethodsCohort study using the California OSHPD 2007–2014 database. Records of pregnant patients were analyzed for gallbladder calculus within four months of delivery. Biliary system interventions were evaluated as the primary exposure....
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionWe present the first risk score model to predict IGBC. The model estimates the expected risk for the individual patient and may help to optimize treatment strategies.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Authors: Zhang J, Si J, Gan L, Guo M, Yan J, Chen Y, Wang F, Xie Y, Wang Y, Zhang H Abstract Cervical cancer is the second most common malignant tumour threatening women's health. In recent years, heavy-ion beam therapy is becoming a newly emerging therapeutic mean of cancer; however, radio-resistance and radiation-induced damage constitute the main obstacles for curative treatment of cervical cancer. Therefore, to identify the radiosensitizers is essential. Here, we investigated the effects of Wnt signalling pathway on the response of 12C6+ radiation in HeLa cells. XAV939, an inhibitor of Wnt signalling pathway, w...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 24 January 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Supreeta Arya, Saugata Sen, Reena Engineer, Avanish Saklani, Tarun PandeyAbstractHigh-resolution phased array external MRI is the first investigation of choice in rectal cancer for local staging, both in the primary and restaging situations. Use of MRI helps differentiate between those with good prognosis, which can be offered upfront surgery and the poor prognostic cases where treatment intensification is needed. MRI identified poor prognostic factors are threatened or involved mesorectal fascia, T3 tumors with> 5mm e...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 24 January 2020Source: Pathology - Research and PracticeAuthor(s): Xiaoyu Gao, Suhua Zhong, Yan Tong, Yushan Liang, Guofei Feng, Xiaoying Zhou, Zhe Zhang, Guangwu HuangAbstractCollagen (COL) genes participate in tumor extracellular matrix (ECM)-receptor interactions and focal adhesion pathways, which play a crucial role in tumor invasion and metastasis. The prognostic value of COL genes has been shown for several malignancies. In the present study, we analyzed multiple microarray datasets using the Oncomine database to identify alterations of COL genes in gastric cancer (GC). Gene express...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionCombined Rendez-vous isthmoplasty is feasible, safe, and effective in experienced hands, giving the surgeon a comprehensive evaluation of the anatomy of the isthmocele, and increasing the odds of a complete resection and restoration of the anatomy 4, 5, 6, 7. In this patient, the procedure was uneventful, without any intra- or postoperative complications, and the symptoms were completely controlled.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
PANCREATIC cancer is when uncontrollable cells multiply within the pancreas. The large gland is part of the digestive system, and so warning signs of the deadly condition could be flushed away in the toilet bowl.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 24 January 2020Source: Microbial PathogenesisAuthor(s): Namita Singh, Priya Prasad, Banashree Das, Sangita RastogiAbstractCytokines might be involved in spontaneous abortion by triggering inflammatory mediators (Cyclooxygenases (Cox)) leading to spontaneous abortion in Chlamydia trachomatis (Ct)-infected women. Study aimed to quantitate the expression of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-8) and Cox-2 in endometrial curettage tissue (ECT) of Spontaneous Aborters (SA). SA (n = 135) and 120 age-matched controls were enrolled from SJH, New Delhi, India. PCR was perf...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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